老年高血压患者脂代谢对血管内皮及肾脏血流参数的影响研究

于艳丽

【摘要】 目的：探究与分析老年高血压患者脂代谢对血管内皮及肾脏血流参数的影响程度。方法：选取2019年1月-2020年5月的90例老年高血压患者为观察组，同时期的90名健康老年人员为对照组。比较两组的血管内皮指标（血清ET-1、vWF及sVCAM-1）及肾脏血流参数（肾主动脉及肾段动脉PSV、EDV及RI），并比较观察组中不同高血脂程度者的上述指标检测结果。采用Spearman秩相关分析血管内皮指标及肾脏血流参数与老年高血压患者高血脂程度的关系。结果：观察组的ET-1、vWF、sVCAM-1水平均显著高于对照组，差异均有统计学意义（P<0.05）。观察组中不同高血脂程度者的ET-1、vWF、sVCAM-1水平比較，差异均有统计学意义（P<0.05）。观察组的肾主动脉、肾段动脉RI均显著高于对照组，肾主动脉、肾段动脉PSV及EDV均显著低于对照组，差异均有统计学意义（P<0.05）。观察组中不同高血脂程度者肾主动脉、肾段动脉的PSV、EDV、RI比较，差异均有统计学意义（P<0.05）。Spearman秩相关分析显示血管内皮指标及肾主动脉及肾段动脉RI与高血脂程度均呈正相关，肾主动脉及肾段动脉PSV及EDV与高血脂程度均呈负相关（P<0.05）。结论：脂代谢对老年高血压患者的血管内皮及肾脏血流参数的影响较大，应重视对高血脂的监测与调控。

【关键词】 老年高血压 脂代谢 血管内皮 肾脏血流参数

Study on the Influence of Lipid Metabolism on Vascular Endothelium and Renal Blood Flow Parameters in Elderly Patients with Hypertension/YU Yanli. //Medical Innovation of China， 2021， 18（16）： -127

[Abstract] Objective： To explore and analyze the influence of lipid metabolism on vascular endothelial and renal blood flow parameters in elderly patients with hypertension. Method： A total of 90 elderly hypertension patients from January 2019 to May 2020 were selected as the observation group， and 90 healthy elderly people during the same period were selected as the control group. Vascular endothelial indexes （serum ET-1， vWF and sVCAM-1） and renal blood flow parameters （PSV， EDV and RI of renal aorta and renal segment arteries） were compared between the two groups. The results of the above indexes were compared in the observation group with different levels of hyperlipidemia. Spearman rank correlation was used to analyze the relationship between vascular endothelial indexes and renal blood flow parameters and hyperlipidemia in elderly patients with hypertension. Result： The levels of ET-1， vWF and sVCAM-1 in the observation group were significantly higher than those in the control group， the differences were statistically significant （P<0.05）. Comparison of the levels of ET-1， vWF and sVCAM-1 in the observation group with different hyperlipidemia grades， the differences were statistically significant （P<0.05）. The RI of renal aorta and renal segment artery in the observation group were significantly higher than those in the control group， and the PSV and EDV of renal aorta and renal segment artery in the observation group were significantly lower than those in the control group， the differences were statistically significant （P<0.05）. Comparison of PSV， EDV and RI of renal aorta and renal segmental artery in observation group with different hyperlipidemia grade， the differences were statistically significant （P<0.05）. Spearman rank correlation analysis showed that vascular endothelial indexes， RI of renal aorta and renal segment artery were positively correlated with the degree of hyperlipidemia， while PSV and EDV of renal aorta and renal segment artery were negatively correlated with the degree of hyperlipidemia （P<0.05）. Conclusion： Lipid metabolism has a great influence on vascular endothelial and renal blood flow parameters in elderly patients with hypertension， so attention should be paid to the monitoring and regulation of hyperlipidemia.

[Key words] Elderly hypertension Lipid metabolism Vascular endothelial Renal blood flow parameters

First-author’s address： Jiamusi Central Hospital， Jiamusi 154002， China

doi：10.3969/j.issn.1674-4985.2021.16.030

高血压在我国具有极高的发病率，而老年患者在其中占比极高，因此老年高血压患者的各方面变化研究均可见，脂代谢作为在高血压患者中研究日益增多的方面，其更为细致的危害研究极为必要。血管内皮损……