MSCT检测的肺容积指标与肺气流限制和弥散能力的相关性

刘亚军

【关键词】 MSCT 肺容积 肺气流限制 弥散能力

[Abstract] Objective： To explore the correlation between lung volume indexes measured by MSCT and pulmonary airflow limitation and diffusion capacity. Method： A total of 200 patients with chronic obstructive pulmonary disease （COPD） who received treatment in our hospital from October 2017 to October 2020 were selected as the study group， and 50 healthy patients who received physical examination in our hospital during the same period were selected as the control group. Chest MSCT and lung function （PET） were performed in both groups. The correlation indexes of MSCT and PET were compared between the two groups， and the correlation between MSCT and PET was analyzed. Result： Vin， Vex and Vex/Vin in the study group were significantly higher than those in the control group， while Vin-Vex was significantly lower than that in the control group， the differences were statistically significant （P<0.05）. TLC and RV in study group were significantly higher than those of control group， DLCO was significantly lower than that of control group， the differences were statistically significant （P<0.05）. Pearson correlation analysis showed that TLC and RV were positively correlated with Vin， Vex and Vex/Vin， but negatively correlated with Vin-Vex （P<0.05）. DLCO was negatively correlated with Vin， Vex and Vex/Vin， but positively correlated with Vin-Vex （P<0.05）. Conclusion： MSCT has a certain correlation with PET related indicators， and MSCT testing can better reflect the relevant situation of lung volume， which is helpful to determine the status of lung function， and has a good clinical application value.

[Key words] MSCT Lung volume Lung airflow limitation Diffusion capacity

First-author’s address： Liaocheng Infectious Disease Hospital， Liaocheng 252000， China

doi：10.3969/j.issn.1674-4985.2021.26.043

肺通气功能是一种能够衡量空气进入肺泡及废气由肺泡排出过程的动态指标，肺通气相关指标是临床上肺功能检测的常用参考[1-3]。以COPD为例，此类患者典型临床表现为持续性的气流受限，且气流受限呈现进行性发展，多数患者伴有气道以及肺对有害颗粒或气体所致慢性炎症反应的增加[4-5]。对COPD患者开展CT检测对临床诊断具有较好的参考意义，能够指导患者临床治疗的展开，有研究指出MSCT检测指标甚至能用于COPD患者预后评估中，近些年随着影像学技术的不断发展，MSCT在临床上的应用愈加广泛[6-7]。一项针对肺气肿患者开展的临床研究发现，MSCT能够准确地反映肺气肿损害部位及分布情况，有助于肺气肿范围及严重程度的确定，相较传统的肺功能评估敏感度更高[8-9]。还有学者的研究指出，通过肺部病变患者与正常人群开展肺容积对照的方式，可以从形态学上较为准确地反映个体肺部病变情况，相比单纯的肺功能监测具有更大的优势[10-11]。肺气流限制与弥散能力都是反映个体肺功能的常用指标，本研究旨在探究MSCT检测的肺容积指标与肺气流限制和弥散能力的相关性，以期为肺功能评估提供新的思路与检查手段。现报道如下。

1 资料与方法

1.1 一般资料 选择2017年10月-2020年10月于本院接受治疗的200例慢性阻塞性肺疾病（COPD）患者为研究组，另选取同期于本院接受体格检查的50名健康体检者为对照组。（1）纳入标准：①均符合慢性阻塞性肺疾病全球倡议（2014版）中COPD诊断标准且出现相应临床症状者[12];②意识清晰能够配合进行调研;③病例资料齐全;④年龄>40岁;⑤住院时间超过24 h。……