复方木芙蓉涂鼻软膏联合辛芩颗粒治疗小儿慢性鼻炎的疗效

肖洋 李正才 曾文娟

[摘要] 目的 探讨复方木芙蓉涂鼻軟膏联合辛芩颗粒治疗小儿慢性鼻炎的疗效。 方法 选取本院2019年7—12月收治的90例慢性鼻炎患儿，随机分为单用组与联用组，每组各45例，单用组给予复方木芙蓉涂鼻软膏1 cm涂于鼻腔出血位置，早、晚各一次;联用组在外用复方木芙蓉涂鼻软膏的基础上再口服辛芩颗粒，比较两组患者的治疗效果及复发情况。 结果 与治疗前比较，治疗1周后联用组症状积分值显著降低（P<0.05），单用组无明显变化（P>0.05），且联用组患儿症状积分值较单用组减少更明显（P<0.05）。经4周治疗后两组患儿治愈率均高于80.00%，但经1周治疗后，联用组显效率高于40.00%，2倍于单用组。经4周治疗后，两组均可明显降低患儿血清CRP的含量（P<0.05），且联用组CRP含量[（6.37±2.14）mg/L]显著低于单用组[（7.50±2.89）mg/L]（P<0.05）。 结论 复方木芙蓉涂鼻软膏联合辛芩颗粒治疗小儿慢性鼻炎迅速有效且疗效稳定，无明显不良反应，值得临床推广。

[关键词] 慢性鼻炎;复方木芙蓉涂鼻软膏;辛芩颗粒;C反应蛋白

[Abstract] Objective To explore the therapeutic efficacy of compound Mufurong nasal ointment combined with Xinqin Granule in treating children with chronic rhinitis. Methods A total of 90 children with chronic rhinitis admitted to our hospital from July 2019 to December 2019 were collected，and they were divided into the single-use group（n=45） and the combined-use group（n=45） randomly. The single-use group was administrated in the morning and before going to bed at night. And the compound Mufurong nasal ointment was applied to the hemorrhage position of nasal cavity for 1 cm long. The combined-use group was administrated on the combination of external compound Mufurong nasal ointment and the oral taken Xinqin Granules. Meanwhile，the therapeutic efficacies and relapses of the two groups were compared. Results The symptom score in the combined-use group after 1 week of treatment was decreased significantly compare with that before treatment（P<0.05）. However， there was no significant change in the single-use group （P>0.05）， and the symptom score in the combined-use group was decreased more significantly than that in the single-use group（P<0.05）. After 4 weeks′treatment， he therapeutic efficacy of children in both groups were all higher than 80%， but after 1 week′s treatment，the significant efficacy of the combined-use group was higher than 40.00%， which was twice as high as that of the single-use group. After 4 weeks′treatment，the content of serum C-reactive protein in both groups was significantly reduced（P<0.05）， and the content of C-reactive protein in the combined-use group（[6.37±2.14]mg/L） was significantly lower than（[7.50±2.89]mg/L） in the single-use group（P<0.05）. Conclusion The compound Mufurong nasal ointment combined with Xinqin Granule are rapid and stable in efficacy of treating children with chronic rhinitis， and there are no obvious adverse reactions， which is worthy of clinical promotion.

[Key words] Chronic rhinitis; Compound Mufurong nasal ointment; Xinqin Granules; C reactive protein

慢性鼻炎是一种鼻腔黏膜和黏膜下层的慢性炎症，常在冬夏之交或雾霾天气发作，主要症状包括鼻塞、鼻漏、鼻后滴涕，有时伴有打喷嚏、鼻痒、头痛等表现[1]。临床上，为减轻患儿鼻塞症状，常使用鼻减充血剂，如麻黄素、羟甲唑啉、四氢唑啉等。但是麻黄素的药物依赖性很强，长时间使用容易引起药物性鼻炎和反跳性鼻塞，羟甲唑啉这一类减充血剂有着与口服麻黄素类相同的副作用，不宜长时间使用。慢性鼻炎属中医学的“鼻窦”范畴，主要是由于本体气虚、外感风寒袭肺、肺失宣泄、上干清窍而致鼻塞。因此，中医治疗慢性鼻炎，多采用消炎、通窍，温中扶正祛邪诸法。儿童由于自身的免疫力较低，经常出现呼吸道感染，而慢性鼻炎是其常见的并发症。如果不及时治疗干预，患儿的心里健康及生长发育都会受到影响。由于患儿对手术的耐受性不理想，因此中成药保守治疗成为一个重要选择[3]。……