陈玉华
[摘要] 目的 探討血常规、PCT、CRP及细菌培养在皮肤疖病中的应用价值。 方法 选择2018年1月至2020年1月本院治疗的120例疖病患者。按随机数字表法分为两组,观察组60例,根据药敏试验结果调整抗生素;对照组60例经验性使用抗生素。收集并比较两组患者的一般资料、入院第1天与治疗第7天的实验室检查结果(WBC计数、NE、PCT、CRP、脓液细菌培养、药敏试验结果)以及住院情况。 结果 两组患者的一般资料对比无统计学意义(P>0.05)。治疗第7天,观察组NE绝对值[(9.35±3.05)×109/L]低于对照组[(10.81±3.28)×109/L],两组比较差异有统计学意义(P<0.05);观察组PCT含量[(0.25±0.03)ng/mL]低于对照组[(0.28±0.03)ng/mL],两组比较差异有统计学意义(P<0.05);观察组CRP水平[(31.26±5.12)mg/L]低于对照组[(46.35±5.15)mg/L],两组比较差异有统计学意义(P<0.05)。细菌培养结果为金黄色葡萄球菌,多重耐药(MDR)菌株为15株(12.50%)。观察组住院时间[(12.63±3.29)d]低于对照组[(18.25±5.45)d],两组比较差异有统计学意义(P<0.05);观察组住院费用[(3206.02±309.25)元]低于对照组[(5604.06±513.84)元],两组比较差异有统计学意义(P<0.05)。 结论 NE、PCT、CRP可用于疖病早期诊断,细菌培养及药敏试验对抗生素的选择、缩短住院时间、减少住院费用具有重要意义。
[关键词] C反应蛋白;药敏试验;疖病;金黄色葡萄球菌
[中图分类号] R632.2 [文献标识码] B [文章编号] 1673-9701(2021)08-0095-04
The application value of blood routine, PCT, CRP and bacterial culture in skin furunculosis
CHEN Yuhua
Department of Dermatology, General Hospital of Fuxin Mining Industry Group Affiliated to Liaoning Health Industry Group, Fuxin 123000, China
[Abstract] Objective To investigate the application value of blood routine, PCT, CRP and bacterial culture in skin furunculosis. Methods A total of 120 patients with furunculosis treated in our hospital from January 2018 to January 2020 were selected, and they were divided into the observation group(n=60) and the control group(n=60) according to the random number table method. In the observation group, antibiotics were adjusted according to the results of drug sensitivity test, while in the control group, antibiotics were treated empirically. The general data, laboratory examination results on the first day of admission and the seventh day of treatment(WBC count, NE, PCT, CRP, pus bacteria culture, drug sensitivity test results) and hospitalization of the two groups of patients were collected and compared. Results There was no statistically significant difference in general data between the two groups of patients(P>0.05). On the seventh day of treatment, the absolute value of NE in the observation group was([9.35±3.05]×109/L), lower than([10.81±3.28]×109/L) in the control group, with statistically significant difference(P<0.05). The PCT content in the observation group was([0.25±0.03] ng/mL), lower than([0.28±0.03] ng/mL) in the control group, with statistically significant difference (P<0.05). The CRP level in the observation group was ([31.26±5.12] mg/L), lower than ([46.35±5.15] mg/L) in the control group, with statistically significant difference (P<0.05). The results of bacterial culture were Staphylococcus aureus, and 15 strains(12.50%) were multidrug resistant(MDR). The hospitalization time of the observation group was ([12.63±3.29] days), lower than([18.25±5.45] days) in the control group, with statistically significant difference(P<0.05). The hospitalization expenses of the observation group were([3206.02±309.25] CNY), lower than([5604.06±513.84]CNY) of the control group, with statistically significant difference(P<0.05). Conclusion NE, PCT and CRP can be used for early diagnosis of furunculosis, and bacterial culture and drug sensitivity test are of great significance for the selection of antibiotics, shortening hospitalization time and reducing hospitalization expenses.
[Key words] C reactive protein; Drug sensitivity test; Furunculosis; Staphylococcus aureus
疖是一种累及毛囊及毛囊周围的原发性深部感染,通常由金黄色葡萄球菌感染引起,可导致脓肿的形成,多部位或反复发作时称为疖病[1,2]。通常,疖病常见的诱因为长期携带金黄色葡萄球菌、患有糖尿病、免疫能力低甚至缺陷、肥胖、卫生条件差等因素引起[3,4]。疖病为特殊的脓肿种类,具有多发性和反复性,伴有红肿热痛,严重影响患者的日常生活,需要进行及时诊断和有效的治疗。日常工作中有临床症状与实验室检查的支持,疖病的诊断并不困难。抗生素治疗及对症支持治疗是治疗疖病的一线治疗方案。但值得注意的是,由于该病主要为金黄色葡萄球菌感染,其次为白色葡萄球菌感染,甚至在肛周位置可为厌氧菌感染[5-7],并且随着耐药菌的日益增多,导致治疗效果较差,肿块消散缓慢,对患者的健康危害极大。因此……