后循环短暂性脑缺血发作患者血浆D-二聚体、纤维蛋白原、血小板的变化

郭建波

【摘要】 目的：觀察与分析后循环短暂性脑缺血发作患者血浆D-二聚体、纤维蛋白原、血小板的变化情况。方法：选取2018年11月-2020年6月本院收治的90例后循环短暂性脑缺血发作患者为观察组，同时期的90名同龄健康者为对照组。比较两组血浆D-二聚体、纤维蛋白原、血小板指标（血小板参数与血小板活化指标），并比较观察组中不同发作频率及发作时间患者的检测结果，采用Pearson相关性分析血浆D-二聚体、纤维蛋白原、血小板指标与后循环短暂性脑缺血发作的关系。结果：观察组PLT显著低于对照组，血浆D-二聚体、纤维蛋白原及其他血小板指标均显著高于对照组，且观察组中发作频率较高及发作时间较长患者PLT均显著低于发作频率较低及发作时间较短患者，血浆D-二聚体、纤维蛋白原及其他血小板指标显著高于发作频率较低及发作时间较短患者，差异均有统计学意义（P<0.05）;Pearson相关性分析显示，血浆D-二聚体、纤维蛋白原、血小板指标均与后循环短暂性脑缺血发作相关（P<0.05）。结论：后循环短暂性脑缺血发作患者的血浆D-二聚体、纤维蛋白原、血小板指标均呈现显著异常的状态，且不同发作频率及发作时间患者的差异显著，因此在后循环短暂性脑缺血发作患者中的检测价值较高。

【关键词】 后循环短暂性脑缺血发作 D-二聚体 纤维蛋白原 血小板

[Abstract] Objective： To observe and analyze the change of plasma D-dimer， fibrinogen and platelet of patients with posterior circulation transient ischemic attack. Method： A total of 90 patients with posterior circulation transient ischemic attack treated in our hospital from November 2018 to June 2020 were chosen as the observation group， 90 healthy persons at the same time were chosen as the control group. Then the plasma D-dimer， fibrinogen and platelet indexes （platelet parameters and platelet activation indexes） of two groups were compared， and the detection results of observation group with different attack frequency and attack time were compared， then the relationship between plasma D-dimer， fibrinogen and platelet indexes and posterior circulation transient ischemic attack were analyzed with Pearson correlation analysis. Result： The PLT of the observation group was significantly lower than that of the control group， the plasma D-dimer， fibrinogen and other platelet indexes were significantly higher than those of the control group， the PLT of the observation group with higher attack frequency and longer attack time were significantly lower than those of patients with lower attack frequency and shorter attack time， the plasma D-dimer， fibrinogen and other platelet indexes were significantly higher than those of patients with lower attack frequency and shorter attack time， there were statistically significant differences （P<0.05）. Pearson correlation analysis showed the plasma D-dimer， fibrinogen and platelet indexes were all close with posterior circulation transient ischemic attack （P<0.05）. Conclusion： The plasma D-dimer， fibrinogen and platelet of patients with posterior circulation transient ischemic attack show significantly abnormal state， and the differences of patients with different attack frequency and attack time are significant， so their detection value in the patients with posterior circulation transient ischemic attack is higher.

[Key words] Posterior circulation transient ischemic attack D-dimer Fibrinogen Platelet

First-authors address： Shijingshan Teaching Hospital of Capital Medical University， Shijingshan Hospital， Beijing 100043， China

doi：10.3969/j.issn.1674-4985.2021.03.015

临床各界对短暂性脑缺血发作的危害认知显著提升，与此同时，与之相关的各方面研究不断增多，而凝血及其他循环相关指标的变化研究是重点[1]。D-二聚体、纤维蛋白原及血小板作为与凝血及循环密切相关的方面，其在短暂性脑缺血发作患者中的变化研究可见的同时，研究结果差异也普遍存在。有研究认为后循环缺血更易进展至严重情况[2-3]，因此针对后循环短暂性脑缺血发作患者的上述方面变化研究更为必要。……