六经论治联合非布司他治疗痛风性关节炎的临床研究

罗才茂 王金萍 李小燕 刘清华 钟宏文 钟王瑜

【摘要】 目的：分析六經论治联合非布司他治疗痛风性关节炎的临床效果。方法：选取2018年6月-2019年12月本院诊治的60例痛风性关节炎患者为研究对象。随机分为对照组（n=30）和观察组（n=30），对照组患者在基础治疗上服用非布司他治疗，观察组在基础治疗上行六经论治联合非布司他治疗。比较两组患者的临床疗效、血清尿酸、不良反应发生情况以及C反应蛋白（CRP）水平。结果：观察组的总有效率96.67%，高于对照组的76.67%，差异有统计学意义（P<0.05）。观察组不良反应发生率为6.67%，低于对照组的30.00%，差异有统计学意义（P<0.05）。治疗前，两组UA及CRP比较，差异均无统计学意义（P>0.05）;治疗后，两组UA及CRP均较治疗前降低，且观察组均低于对照组，差异均有统计学意义（P<0.05）。结论：六经论治联合非布司他治疗痛风性关节炎临床效果较好，可以降低患者血清尿酸水平，能够减少不良反应发生以及降低患者血清炎症因子的水平，临床应用价值高。

【关键词】 六经论治 非布司他 痛风性关节炎

Clinical Study on Treatment of Gouty Arthritis with Six Meridians Combined with Febuxostat/LUO Caimao， WANG Jinping， LI Xiaoyan， LIU Qinghua， ZHONG Hongwen， ZHONG Wangyu. //Medical Innovation of China， 2021， 18（13）： -114

[Abstract] Objective： To analyze the clinical effect of six meridians combined with Febuxostat in the treatment of gouty arthritis. Method： A total of 60 patients with gouty arthritis in our hospital from June 2018 to December 2019 were selected as the research objects. They were randomly divided into control group （n=30） and observation group （n=30）， the patients in the control group were treated with Febuxostat on the basis of basic treatment， the observation group was treated with six meridians combined with Febuxostat. The clinical efficacy， serum uric acid， adverse reactions and C-reactive protein （CRP） levels of the two groups were compared. Result： The total effective rate of the observation group was 96.67%， which was higher than 76.67% of the control group， the difference was statistically significant （P<0.05）. The incidence of adverse reactions in the observation group was 6.67%， which was lower than 30.00% in the control group， the difference was statistically significant （P<0.05）. Before treatment， there were no significant differences in UA and CRP between the two groups （P>0.05）. After treatment， UA and CRP in the two groups were lower than those of before treatment， and the observation group were lower than those of the control group， the differences were statistically significant （P<0.05）. Conclusion： The clinical effect of six meridians combined with Febuxostat in the treatment of gouty arthritis is good， which can reduce the level of serum uric acid， reduce the occurrence of adverse reactions and reduce the level of serum inflammatory factors， and has high clinical application value.

[Key words] Six meridians Febuxostat Gouty arthritis

First-authors address： Peoples Hospital of Ganxian District， Ganzhou 341100， China

doi：10.3969/j.issn.1674-4985.2021.13.027

痛风性关节炎（GA）是因尿酸排泄降低或是体内嘌呤代谢紊乱，造成患者血尿酸水平异常升高的代谢综合征[1]。其根本原因是尿酸过于饱和导致析出晶体式沉积，致使患者关节囊、软骨、滑囊等组织尿酸盐异常积聚，从而使沉积部位发生炎症[2]。痛风性关节炎临床特点是反复出现关节炎症状、造成患者痛风石形成，严重可导致患者肾脏出现相关问题，如尿酸肾结石或间质性肾炎等[3]，严重影响患者的生命健康。随着物质条件的改变，人们饮食中高嘌呤较多，导致痛风性关节炎的发病率也愈来愈高，目前有报道指出我国GA的发病率在1%～3%，且发病对象主要集中在男性[4]。目前国内外研究学者均认为药物治疗痛风的主要机制为降尿酸达标治疗，维持尿酸水平低于356 μmol/L（6.0 mg/dL）[5]。然而，传统药物降尿酸疗法虽然有效，但是长久服用会经常性刺激胃肠道、损伤胃肠道功能，而且复发的可能性较高，临床治疗效果难以令人满意[6]。……