小儿解感颗粒治疗小儿急性上呼吸道感染的临床观察

王楠 张金虎

摘要 目的：探討小儿解感颗粒对小儿急性上呼吸道感染（AURI）治疗的临床效果评价及安全性。方法：选取2018年2月至2019年2月西安市儿童医院儿科门诊收治的AURI患儿108例作为研究对象，随机分为观察组和对照组，每组54例。观察组给予小儿解感颗粒治疗，对照组给予小儿热速清颗粒治疗。连续治疗3 d后对2组患病儿童的临床疗效、退热时间、症状积分、血清炎性反应细胞因子水平、不良反应发生情况等数据收集整理，统计分析。结果：治疗一周期后观察组治愈率高和显效率均高于对照组，有效率和无效率低于对照组，总有效率高于对照组（P<0.05）。观察组退热起效时间和完全退热时间均低于对照组（P<0.05）。经治疗后观察组发热、咽喉部红肿痛、鼻塞等症候积分均低于对照组（P<0.05）。治疗后观察组血清炎性反应细胞因子水平低于对照组（P<0.05）。治疗期间对照组出现腹泻3例，呈水样便，皮疹1例，观察组患儿未见不良反应发送，2组组间不良反应发生率有明显差异（P<0.05）。结论：与小儿热速清颗粒比较，小儿解感颗粒可减少患儿发热持续时间，改善患儿症候，降低血清炎性反应细胞因子水平，用于小儿AURI的临床治疗，疗效显著，安全，临床可推广。

关键词 急性上呼吸道感染;小儿解感颗粒;小儿热速清颗粒;临床疗效;退热时间;炎性反应因子;不良反应

Clinical Observation of Xiaoer Jiegan Granule in the Treatment of Children′s Acute Upper Respiratory Tract Infection

WANG Nan，ZHANG Jinhu

（Xi′an Children′s Hospltal，Xi′an 710004，China）

Abstract Objective：To study the clinical efficacy and safety of Xiaoer Jiegan Granule in the treatment of acute upper respiratory tract infection in children.Methods：A total of 108 child patients with acute upper respiratory tract infection admitted to Pediatric Department of Xi′an Children′s Hospltal from February 2018 to February 2019 were randomly divided into an observation group and a control group，with 54 cases in each group.The observation group was treated with Xiaoer Jiegan Granule，while the control group was treated with Xiaoer Resuqing Granule.After 3 days of continuous treatment，the clinical efficacy，antipyretic time，symptom score，serum inflammatory cytokine level，incidence of adverse reaction and theother data of the 2 groups were compared.Results：After 1 cycle of treatment，the observation group had a higher curative rate，which was significantly higher than the control group.The effective rate and inefficiency were lower than those of the control group，and the total effective rate was higher than that of the control group（P<0.05）.Antipyretic onset time in the observation group and complete antipyretic time were lower than the control group（P<0.05）.After treatment，the scores of symptoms such as fever，throat swelling and pain，and nasal congestion in the observation group were lower than those in the control group.After treatment，the serum inflammatory factors in the observation group were lower than that in the control group（P<0.05）.During the treatment period，there were 3 cases of watery stool diarrhea and 1 case of skin rash in the control group，and no adverse reactions occurred in the observation group.There were significant differences in the incidence of adverse reactions between the 2 groups（P<0.05）.Conclusion：Compared with Xiaoer Resuiqing Granule，Xiaoer Jiegan Granule can shorten the time offever abatement，improve the symptoms of child patients，reduce the level of Serum inflammatory cytokine.It is used for the clinical treatment of pediatric AURI，with remarkable curative effect and safety.And it can be used for clinical promotion.

Keywords Acute upper respiratory infection; Xiaoer Jiegan Granules; Xiaoer Reseqing Granules; Clinical efficacy; Antipyretic time; Inflammatory factors; Adverse reactions

中图分类号：R242;R272文献标识码：Adoi：10.3969/j.issn.1673-7202.2021.02.019

小儿急性上呼吸道感染（Acute Upper Respiratory Infection，AURI）是儿科呼吸科中最为常见的，是由于小儿对外界病毒、细菌等致病微生物侵袭的抵抗力较弱，进而导致该疾病的发生[1]。患儿通常起病急促，發病后表现为发热、咽部、喉部或扁桃体的红肿疼痛、鼻塞、流涕等症状，对患病儿童正常的生长发育产生一定影响，同时对其身体的健康情况和生命质量产生一定的影响[2]。因小儿患者自身抵抗力弱，若不及时治疗可造成病情迁延不愈，病情迁延下呼吸道，甚至导致肺炎、支气管炎等下呼吸道的感染的发生，加重患儿病情[3]。目前，常规的西医治疗手段有解热镇痛、抗炎抗感染、镇咳祛痰、抗过敏等治疗药物，但目前除流感病毒外，尚无特效治疗药物用于单纯性病毒感染所致AURI。……