基于数据挖掘中药治疗气阴两虚型室性早搏的用药规律研究

张文杰 查玉玲 李军

摘要 目的：基于数据挖掘技术总结中药治疗气阴两虚型室性早搏的用药规律。方法：采用计算机检索与人工检索相结合的方法，运用主题词检索方法检索2010年3月至2020年3月国家知识基础设施数据库（CNKI）、中國学术期刊数据库（CSPD）、中文科技期刊数据库（CCD）、中国生物医学文献数据库（CBM）4个数据库中中医药治疗气阴两虚型室性早搏临床研究的相关文献，运用Excel 2010建立数据库并结合IBM SPSS Statistics 20.0对其用药规律进行分析。结果：共纳入106篇文献，涉及中药112味;方剂应用率>50%的药物有麦冬、炙甘草、五味子;药物功效分类中，使用频次最高的为补虚药，其次为安神药和活血化瘀药。聚类分析中，提取5对药对及3组药物组合。结论：气阴两虚型室性早搏以益气养阴为治法，方药以补虚药为核心，辅以安神药，佐以活血化瘀药，治疗的核心药物为麦冬、炙甘草、酸枣仁、丹参，聚类分析结果对于指导临床有重要意义。

关键词 气阴两虚型;室性早搏;中药功效;用药规律;聚类分析;益气养阴;安神;活血化瘀

Abstract Objective：To explore the prescribing regulairty of traditional Chinese medicine（TCM）compound prescription of premature ventricular contractions of deficiency of qi and yin type based on data mining technology.Methods：Through computer retrieval and manual screening，the clinical research literatures on the treatment with Chinese medicine for premature ventricular contractions of deficiency of qi and yin type（CNKI、CSPD、CCD、Sinomed）from March 2010 to March 2020 were searched using the keyword search method to search，in order to establish a database by Excel 2010 and to analyze the clinical prescribing regularity with IBM SPSS Statistics 20.0.Results：A total of 106 literature were included，with 112 kinds of traditional Chinese drugs.The drugs whose applied rate in Chinese medicine compound was more than 50% were Radix Ophiopogonis，baked licorice and Fructus Schisandrae Chinensis.According to the classification by efficacy of TCM，the most frequently used drugs had efficacy of tonifying deficiency，sedation，promoting blood circulation and removing blood stasis medicine.Cluster analysis revealed five pairs of commonly used drugs and three groups of medicines.Conclusion：The treatment focus of premature ventricular contractions is benefiting qi and nourishing yin，while the prescription uses tonifying deficiency drugs as its core，supplemented by sedative and promoting blood circulation and removing blood stasis drugs.The core drugs were Radix Ophiopogonis，Baked Licorice，Semen Ziziphi Spinosa and Radix Salviae Miltiorrhizae.The result of cluster analysis has vital significance for guiding the clinical practice.

Keywords Deficiency of qi and yin; Premature ventricular contractions; Efficacy of traditional Chinese medicine; Prescribing regularity; Cluster analysis; Benefiting qi and nourishing yin; Sedative; Promoting blood circulation and removing blood stasis

中图分类号：R256.2文献标识码：Adoi：10.3969/j.issn.1673-7202.2021.10.025

室性早搏，亦称室性期前收缩（Premature Ventricular Contractions，PVCs），是指His束及分支以下心室肌的异位兴奋灶提前除极而产生的心室期前收缩，是临床上最常见的心律失常。现代医学目前治疗方法主要采用抗心律失常药或射频消融术，但都存在一定不足。中医药治疗有一定特色，其整体观念的治疗理念、辨证论治的个体化治疗方法，使患者更易接受。中医药辨证治疗室性早搏的临床报道众多，对室性早搏患者中医辨证分型的回顾性分析表明，气阴两虚证是室性早搏临床最常见证型之一[1-2]。对……