芪苈强心胶囊联合西药治疗慢性心衰40例临床观察

孙思思 许祖建 李雪梅

【摘 要】 目的：观察芪苈强心胶囊联合西药治疗慢性心衰的临床疗效。方法：将80例慢性心衰后伴睡眠障碍患者，随机分为对照组（予以西医常规治疗）、观察组（在对照组基础上加芪苈强心胶囊）各40例。比较两组治疗后心功能[血浆脑钠肽（BNP）、左室舒张末期内径（LVEDD）、左室射血分数（LVEF）值）]及匹兹堡睡眠质量指数（PSQI评分）及总有效率。结果：治疗4月后，对照组与观察组心功能指标比较，BNP、LVEDD均下降、LVEF均升高，且观察组上述各指标明显优于对照组，差异有统计学意义（P<0.05）;对照组PSQI总分高于观察组，差异有统计学意义（P<0.05）;对照组有效率低于观察组，差异有统计学意义（P<0.05）。结论：芪苈强心胶囊联合西药治疗慢性心衰患者，可改善其心功能，提高睡眠质量。

【关键词】 芪苈强心胶囊;慢性心衰;心功能;睡眠质量

【中图分类号】R541.6   【文献标志码】 A    【文章编号】1007-8517（2021）19-0091-04

Clinical Observation on 40 Cases of Chronic Heart Failure Treated by Qiliqiangxin Capsule Combined with Western Medicine

SUN Sisi1 XU Zujian2* LI Xuemei1

1.Graduate School of Anhui University of Traditional Chinese Medicine， Hefei 230000，China;2.First Affiliated Hospital of Anhui University of Traditional Chinese Medicine， Hefei 230000，China

Abstract：Objective To observe the clinical effect of Qiliqiangxin capsule combined with western medicine on heart function and sleep quality of chronic heart failure. Methods 80 patients with sleep disorder after chronic heart failure were randomly divided into control group （treated with routine western medicine） and observation group （treated with Qiliqiangxin capsule on the basis of control group）， with 40 cases in each group. The cardiac function （plasma brain natriuretic peptide （BNP）， left ventricular end diastolic diameter （LVEDD）， left ventricular ejection fraction （LVEF））， Pittsburgh Sleep Quality Index （PSQI） and total effective rate were compared between the two groups after treatment. Results Compared with the observation group， BNP and LVEDD decreased and LVEF increased after 4 months of treatment， and the above indexes in the observation group were significantly better than those in the control group （P<0.05）. The total score of PSQI in control group was higher than that in observation group （P<0.05）. The effective rate of control group was lower than that of observation group， and the difference was statistically significant （P<0.05）.Conclusion Qiliqiangxin capsule combined with western medicine can improve the heart function and sleep quality of patients with chronic heart failure.

Key words：Qiliqiangxin Capsule; Chronic Heart Failure; Cardiac Function;Sleep Quality

心血管疾病發病率逐年上升，多见于中老年人，慢性心力衰竭为其最终转归，5年病死率可高达50%。心衰发生后，主要表现为心肌缺血症状，严重影响患者生活质量，患者往往被迫卧床，情绪焦虑，对疾病和死亡的恐惧严重影响睡眠质量[1]。患者睡眠质量不佳，造成内分泌紊乱，肾上腺素和儿茶酚胺分泌增加，导致心率、呼吸、血压升高，心肌缺血加重，病情恶化， 因此，有效干预抑制心室重构，改善心功能及睡眠质量尤为重要。大量研究[2]证实芪苈强心胶囊具有减少心肌纤维化、减弱心肌收缩、抑制RAAS相关因子释放等作用。此次观察芪苈强心胶囊联合西药治疗慢性心衰，取得较好疗效，现报告如下。

1 临床与方法

1.1 一般资料 选取安徽中医药大学第一附属医院2019年12月至2020年6月心血管内科住院及门诊的慢性心衰合并睡眠障碍患者80例，随机分为对照组和观察组各40例。……