糠酸莫米松乳膏联合维A酸乳膏治疗黄褐斑的效果及安全性

王媛 魏兰兰

[摘 要]目的 分析对黄褐斑患者采用糠酸莫米松乳膏联合维A酸乳膏治疗的效果及安全性。方法 选择空军军医大学第二附属医院2022年1月-12月收治的70例黄褐斑患者为研究对象，随机分为对照组和观察组，每组35例。对照组予以维A酸乳膏治疗，观察组予以糠酸莫米松乳膏联合维A酸乳膏治疗，比较两组症状积分、临床疗效、生活质量及不良反应发生情况。结果 观察组治疗后症状积分低于对照组（P<0.05）；观察组治疗总有效率为94.29%，高于对照组的74.29%（P<0.05）；观察组治疗后生活质量各项评分均高于对照组（P<0.05）；两组不良反应发生率比较，差异无统计学意义（P>0.05）。结论 维A酸乳膏联合糠酸莫米松乳膏治疗黄褐斑的效果良好，可改善患者的临床症状，有利于提升其生活质量，同时联合应用的安全性较高，不会增加不良反应发生风险。

[关键词] 糠酸莫米松乳膏；维A酸乳膏；黄褐斑

[中图分类号] R758.4+2 [文献标识码] A [文章编号] 1004-4949（2024）05-0017-04

Efficacy and Safety of Mometasone Furoate Cream Combined with Tretinoin Cream in the Treatment of Chloasma

WANG Yuan， WEI Lan-lan

（Pharmacy Department of the Second Affiliated Hospital of Air Force Medical University， Xian 710038， Shaanxi， China）

[Abstract]Objective To analyze the efficacy and safety of the combination of mometasone furoate cream and tretinoin cream in the treatment of chloasma. Methods A total of 70 patients with chloasma admitted to the Second Affiliated Hospital of Air Force Medical University from January to December 2022 were randomly divided into control group and observation group， with 35 patients in each group. The control group was treated with vitamin A acid cream， and the observation group was treated with mometasone furoate cream combined with tretinoin cream. The symptom scores， clinical efficacy， quality of life and adverse reactions were compared between the two groups. Results After treatment， the symptom score of the observation group was lower than that of the control group （P<0.05）. The total effective rate of treatment in the observation group was 94.29%， which was higher than 74.29% in the control group （P<0.05）. After treatment， the scores of quality of life in the observation group were higher than those in the control group （P<0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （P>0.05）. Conclusion The combination of tretinoin cream and mometasone furoate cream has a good effect in the treatment of chloasma， which can improve their clinical symptoms and quality of life. At the same time， the combined application has high safety and will not increase the risk of adverse reactions.

[Key words] Mometasone furoate cream； Tretinoin cream； Chloasma

黄褐斑（chloasma）也称为蝴蝶斑，是一种以面颊两侧對称存在黄褐色素沉着为特征的皮肤病，属于脸部色素代谢异常疾病，且在女性中的发病率高于男性。目前关于黄褐斑的病因临床尚未明确，多认为内分泌紊乱、遗传及紫外线照射等与其发生、发展相关[1]。近年来，临床针对黄褐斑的治疗方法很多，且无统一标准，不同疗法的疗效上存在较大差异。其中，维A酸乳膏可以干扰黑色素的正常代谢，加快表皮更新，缩短更新周期，促使表皮脱落，消除黑素微粒。此外，维A酸乳膏还具有减少酪氨酸酶、DA色素转换因子及黑色素的合成等作用，与其他药合用能更好地促进药物的穿透，增强药效[2]。而糠酸莫米松软膏是一种临床上常用的一种糖皮质类固醇，主要用于治疗局部皮肤炎症，可减少嗜酸性粒细胞的活力，从而有效地防止细菌感染。……