左卡尼汀治疗老年冠心病心衰的疗效探讨

熊睿

[摘要] 目的 探讨左卡尼汀治疗老年冠心病心衰的临床疗效。 方法 整群选取2013年8月—2015年8月期间该院收治的84例老年冠心病心衰患者作为研究对象，随机分为两组，每组42例，对照组采用常规治疗方法治疗，观察组在此基础上加用左卡尼汀治疗，详细记录记录两组老年人的治疗前后的LVEF、LVDD等指标。结果 观察组治疗总有效的例数为38例，对照组为32例，观察组的治疗总有效率为90.5%，对照组为74.4%，对比结果差异有统计学意义（P<0.05）；两组对比，观察组治疗后的全部指标都明显优于对照组，对比结果差异有统计学意义（P<0.05）。结论 左卡尼汀辅助治疗老年冠心病心衰，有助于改善心功能。

[关键词] 冠心病；左卡尼汀；老年；临床效果

[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2015）12（a）-0050-03

[Abstract] Objective To study the clinical curative effect of levocarnitine in treatment of senile coronary heart disease and heart failure. Methods 84 patients with senile coronary heart disease and heart failure treated in our hospital from August 2013 to August 2015 were selected as the research object and randomly divided into two groups with 42 cases in each. The control group received conventional treatment method， the observation group received additional levocarnitine treatment on the basis of conventional treatment method. The indicators of LVEF and LVDD of the two groups before and after operation were recorded in detail. Results The total effective cases was 38 in the observation group and 32 in the control group， the total effective rate was 90.5% in the observation group and 74.4% in the control group， the comparison results were obviously different （P<0.05）. After treatment， all indicators in the observation group were obviously better than those in the control group， and the comparison results were obviously different（P<0.05）. Conclusion Levocarnitine in auxiliary treatment of senile coronary heart disease heart failure contributes to improving heart function.

[Key words] Coronary heart disease； Levocarnitine； Senile； Clinical effect

冠心病是老年人的常见病、多发病，冠心病导致心肌长期缺血、缺氧、心肌微循环灌注不足，从而使冠脉内血流减少而发生心衰，因此老年冠心病患者多伴有心衰[1]。左卡尼汀是一种小分子氨基酸衍生物，脂肪氧化和其他主要代谢途径中起着重要作用[2]。它促进糖氧化、调节糖和脂肪酸氧化的平衡，减少缺血期长链脂酰肉碱的堆积对心肌的毒性作用等，使心肌能量代谢得以恢复，预防和减轻心肌损伤[3]。该研究整群选取2013年8月—2015年8月期间该院收治的84例老年冠心病心衰患者作为研究对象，旨在通过观察左卡尼汀治疗冠心病心衰时的指标变化，评价其临床价值。报道如下。

1 资料与方法

1.1 一般资料

该次研究将来该院就诊的84例冠心病心衰高龄患者作为研究对象，其中男性54例，女性30例，年龄60～87岁，按照美国纽约心脏病学会分级标准（HYHA）进行心功能分级。随机分为观察组和对照组，每组各42例，其中观察组男28例，女14例，平均（77.2±5.6）岁，10例为Ⅱ级，24例为Ⅲ级，8例为Ⅳ级；……