不同强度运动结合共轭亚油酸对青春期肥胖大鼠能量代谢、体重及Lee`s指数的影响Effects of Different Intensity Exercise Combine with Conjugated Linoleic Acid on Energy Metabolism, Weight and Lee`s Index of Adolescent Obese Rats

吴 琳，柏友萍，林 潺，张皓月，陈 晨，崔嘉琴WU Lin, BAI Youping, LIN Chan, et al



不同强度运动结合共轭亚油酸对青春期肥胖大鼠能量代谢、体重及Lee`s指数的影响
Effects of Different Intensity Exercise Combine with Conjugated Linoleic Acid on Energy Metabolism, Weight and Lee`s Index of Adolescent Obese Rats

吴 琳，柏友萍，林 潺，张皓月，陈 晨，崔嘉琴
WU Lin, BAI Youping, LIN Chan, et al

摘 要：目的：探讨不同强度运动结合共轭亚油酸（CLA）在8周减肥过程中对青春期肥胖大鼠能量代谢、体重及Lee`s指数的影响。方法：大鼠建模7周后，取40只肥胖倾向大鼠随机分为5组，每组8只，分别为OC、OCC、OLC、OMC、OHC组，低、中、高运动强度分别定为15-18m/min、21-25 m/min、28-32 m/min，时间 60min/天，CLA灌喂1.6g/kg，5次/周，持续8周。每周测体重、体长、计算Lee`s指数，采用大鼠代谢系统测大鼠运动后即刻状态耗氧量和能量消耗。结果：8周干预过程中，耗氧量和能量消耗表现为OCC组高于OC组（P<0.01），OLC、OMC、OHC组均高于OCC组（P<0.05，P<0.01）；体重表现为OLC、OMC、OHC组体重增长幅度均明显低于OC、OCC组（P<0.05，P<0.01），Lee`s指数均表现第8周干预组低于对照组（P＜0.05，P＜0.01）；不同强度运动之间的各项指标无明显差异（P>0.05）。结论：青春期肥胖大鼠伴随周龄的增加体重呈上升趋势，而肌肉吸氧量和总吸氧量、肌肉耗能和总耗能呈下降趋势，8周不同干预方法均能抵抗其下降，并且能抑制体重增长幅度和降低Lee’s指数，运动结合CLA优于单纯补充CLA，受运动强度影响较小。

关键词：运动强度；共轭亚油酸；能量代谢；体重；Lee’s指数

Abstract:Objective: To explore effects of different intensity exercise combine with conjugated linoleic acid（CLA）on energy metabolism、weight and Lee`s index in the process of 8 weeks to lose weight of adolescent obese rats. Methods: The model of rats after 7 weeks, 40 rats of obese prone rats were divide into 5 groups randomly, 8rats in each groups (OC, OCC, OLC, OMC, OHC) Low, medium and high intensity in animal treadmill running speed respectively to 15-18m/min, 21-25 m/min, 28-32 m/min, time is 60min/days, CLA fed 1.6g/kg, 5 times/week, for 8 weeks. Measured the weight, length, calculate Lee`s index every week. Oxygen consumption and energy consumption of immediately after exercise were measured by using rat metabolic system. Results: Intervention in the process for during 8 weeks, oxygen consumption and energy consumption showed that OCC group was higher than that of OC group (P<0.01), OLC, OMC, OHC group were higher than that of group OCC (P<0.05, P<0.01); the body weight growth rate of OLC, OMC, OHC was significantly lower than that of group OC, group OCC (P<0.05, P<0.01), Lee`s index showed intervention group were lower than that of the control group in the eighth weeks (P < 0.05, P < 0.01); the indicators no significant difference between different intensity exercise (P>0.05). Conclusion: The body weight of adolescent obese rats was on the increase with the increase of age, but the muscle oxygen consumption and total oxygen consumption, muscle energy consumption and total energy consumption was on the reduce, different intervention methods with eight weeks can inhibit that reduce, and can inhibit weight growth and reduce Lee 'sbook=33,ebook=38index, exercise combined with CLA is superior to that of simple supplementation of CLA, less affected by exercise intensity．

Key words:Exercise intensity; Conjugated linoleic acid; Energy metabolism; Body weight; Lee`s index

近年来，肥胖症患病率不断增加，而且这种趋势在儿童和青少年中更为突出[1]。肥胖与2型糖尿病、高血脂、高血压及心脑血管疾病等慢性疾病密切相关，严重影响现代人的身心健康和生活质量[2]。青少年正处于生长发育阶段，能量代谢非常活跃，能量消耗巨大，需要大量的营养物质，一般不容易引起肥胖。青少年一旦肥胖，患各种慢性疾病的危险性较高，且很大概率上会发展为成人肥胖[3]。因此，青少年肥胖问题不容忽视。……