加巴喷丁治疗神经根型颈椎病的临床效果分析

张如坚

【摘要】 目的：分析加巴噴丁治疗神经根型颈椎病的临床效果。方法：选择笔者所在医院2017年3月-2018年12月收治的90例神经根型颈椎病患者，按入院单双号将其分为常规组（45例）与治疗组（45例）。常规组采取塞来昔布等常用药物治疗，治疗组在常规组基础上加用加巴喷丁治疗。观察两组疼痛改善情况、颈椎功能恢复情况、睡眠质量和日常活动情况、症状缓解时间、临床疗效及不良反应。结果：治疗组VAS评分、NDI指数、AIS评分低于常规组，ADL评分高于常规组，差异均有统计学意义（P<0.05）。治疗组椎间孔挤压阳性消失时间、颈椎活动能力恢复时间、手指麻木感消失时间均显著早于常规组，差异有统计学意义（P<0.05）。治疗组临床治疗总有效率为95.56%，高于常规组的82.22%，差异有统计学意义（P<0.05）。两组不良反应发生率比较，差异无统计学意义（P>0.05）。结论：加巴喷丁治疗神经根型颈椎病效果确切，颈椎功能恢复快，可减轻患者痛苦，副作用低，值得推广应用。

【关键词】 加巴喷丁 神经根型颈椎病 颈椎功能 临床疗效

doi：10.14033/j.cnki.cfmr.2019.28.012 文献标识码 B 文章编号 1674-6805（2019）28-00-03

Clinical Effect of Gabapentin in the Treatment of Cervical Spondylotic Radiculopathy/ZHANG Rujian. //Chinese and Foreign Medical Research， 2019， 17（28）： -31

[Abstract] Objective： To analyze the clinical effect of Gabapentin in the treatment of cervical spondylotic radiculopathy. Method： A total of 90 patients with cervical spondylotic radiculopathy admitted in our hospital from March 2017 to December 2018 were selected. The patients were divided into the routine group （45 cases） and the treatment group （45 cases）. The routine group was treated with Celecoxib and other commonly used drugs， while the treatment group was treated with Gabapentin on the basis of the routine group. The improvement of pain， recovery of cervical spine function， sleep quality and daily activities， time of symptom relief， clinical efficacy and adverse reactions were observed and compared between the two groups. Result： The VAS score， NDI index and AIS score in the treatment group were lower than those in the routine group， the ADL score was higher than that in the routine group， the differences were statistically significant （P<0.05）. In the treatment group， the disappearance time of positive intervertebral foramen extrusion， recovery time of cervical spine activity and disappearance time of finger numbness were significantly earlier than those in the routine group， the differences were statistically significant （P<0.05）. The total effective rate of the treatment group was 95.56%， which was higher than 82.22% of the routine group， the difference was statistically significant （P<0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （P>0.05）. Conclusion： Gabapentin has a definite effect in the treatment of cervical spondylotic radiculopathy. It can recover cervical spine function quickly， alleviate the pain of patients， and has low side effects. It is worth popularizing and applying.

[Key words] Gabapentin Cervical spondylotic radiculopathy Cervical spine function Clinical effect

First-authors address： Peoples Hospital of Shanwei， Shanwei 516600， China

神经根型颈椎病在临床中极为常见，其发生原因与患者自身生活习惯、工作方式、不良姿势等因素密切相关[1]。随着社会的发展，经济结构的变化，人们的生活与工作方式也随之改变，长期保持不良姿势和缺乏运动可使肩颈压力不断增大，导致该疾病发生率不断上升，患者年龄也越来越年轻化[2]。如今，颈椎疾病已经成为人们面临的重要健康问题，给患者生活与工作带来严重不便。临床治疗神经根型颈椎病的机制主要为肌松、镇痛、抗炎等，通过松弛肩颈部肌肉，改善病变颈椎处炎症，从而缓解疼痛感，使患者恢复正常活动能力[3]。加巴喷丁属于一种常用抗癫痫药，但有研究发现，该药物对于神经性疼痛也具有良好改善作用[4]。……