rTMS辅助帕利哌酮治疗精神分裂症合并强迫症状的效果

林雪飞

【摘 要】目的：探讨重复经颅磁刺激（rTMS）辅助帕利哌酮治疗精神分裂症合并强迫症状的效果。方法：前瞻性选取我院2020年6月—2021年4月收治的精神分裂症合并强迫症状患者共100例，将100例患者采用数字表法分为对照组以及研究组，每组50例。对照组患者采用帕利哌酮进行药物治疗，研究组患者采用重复经颅磁刺激辅助帕利哌酮治疗。对比两组患者的治疗效果、不良反应情况。结果：研究组治疗有效率为96.0%显著高于对照组82.0%（P<0.05）。研究组不良反应发生率低于对照组，组间比较差异有统计学意义（P<0.05）。结论：重复经颅磁刺激辅助帕利哌酮治疗精神分裂症伴随强迫症，疗效显著且安全性较好。对患者的认知功能以及社会功能改善较为显著。

【关键词】重复经颅磁刺激；帕利哌酮；精神分裂症合并强迫症状

Effect of rTMS combined with paliperidone in the treatment of schizophrenia complicated with obsessive-compulsive symptoms

Lin Xuefei

Department of Psychiatry， Xuzhou Guangci Hospital， Jiangsu Xuzhou 221400，China

【Abstract】Objective： To investigate the effect of repeated transcranial magnetic stimulation （rTMS） combined with paripipidone in the treatment of schizophrenia complicated with obsessive-compulsive symptoms. Methods： A total of 100 patients with schizophrenia complicated with obsessive-compulsive symptoms treated in our hospital from June 2020 to April 2021 were prospectively selected.100 patients were divided into control group and study group by digital table method， with 50 cases in each group. The patients in the control group were treated with pareidone， and the patients in the study group were treated with repeated transcranial magnetic stimulation assisted with pareidone. The efficacy and incidence of adverse reactions were compared between the two groups. Results： The effective rate of the study group was 96.0%， which was significantly higher than 82.0% in the control group（P<0.05）. The incidence of adverse reactions in the study group was 8.0%， which was lower than 24.0% in the control group， there was significant difference between the groups（P<0.05）.Conclusion： Repeated transcranial magnetic stimulation combined with paliperidone is effective and safe in the treatment of schizophrenia with obsessive-compulsive disorder. The cognitive function and social function of patients were significantly improved.

【Key？Words】Repeated transcranial magnetic stimulation； Paliperidone； Schizophrenia with obsessive-compulsive symptoms

精神分裂癥是一种思维、意志、行为、情感功能障碍以及精神活动不协调的精神疾病，强迫症是精神分裂症常见的伴随症状，病程越长伴随的强迫症症状一般会越明显，强迫症与精神分裂症的发生、发展、转归密切相关[1]。本次研究探讨rTMS辅助帕利哌酮治疗精神分裂症合并强迫症状的效果及对血清PRL、BDNF水平的影响，为临床治疗提供依据。

1.1 一般资料

前瞻性选取我院2020年6月至2021年4月收治的精神分裂症合并强迫症状患者共100例，将100例患者采用数字表法分为对照组以及研究组，每组50例。研究组，男性34例，女性16例，年龄25岁～64岁，平均年龄（35.63±5.32）岁，病程10月～34月，平均病程（18.11±3.61）月；对照组，男35例，女15例，年龄24岁～65岁，平均年龄（34.82±4.77）岁，病程10月～35月，平均病程（18.21±4.02）月。……