血清tau蛋白、S100蛋白水平与早产儿神经损伤的相关性

范海博

[摘要] 目的 探讨血清tau蛋白、S100蛋白水平与早产儿神经损伤的相关性。 方法 收集2019年2月至2020年2月我院收治的早产儿80例临床资料，将存在脑损伤的40例早产儿研究资料纳入观察组，将无脑损伤的40例早产儿研究资料纳入对照组。记录两组新生儿神经行为（NBNA）评分，并检测血清tau蛋白、S100蛋白水平，分析血清tau蛋白、S100蛋白水平与早产儿神经损伤的相关性。 结果 观察组出生后1周NBNA评分为（28.11±2.28）分，明显低于对照组的（37.82±1.51）分，差异有统计学意义（t=22.457，P=0.000）。观察组出生后1周S100蛋白水平为（209.42±30.20）ng/L、tau蛋白水平为（8.54±2.21）ng/L，均高于对照组的[（180.35±22.06）ng/L、（5.62±1.53）ng/L]，差异有统计学意义（P<0.05）;经Pearson相关性分析显示，血清tau蛋白、S100蛋白水平与早产儿NBNA评分呈负相关（r=-0.442、-0.557，P<0.05）。 结论 早产儿神经损伤与血清tau蛋白、S100蛋白水平相关，通过该血清检测可评估脑损伤，为临床诊疗及预后评估提供参考依据。

[关键词] 神经损伤;早产儿;Tau蛋白;S100蛋白;相关性

[中图分类号] R722.12          [文獻标识码] B          [文章编号] 1673-9701（2021）06-0134-03

Correlation between serum tau and S100 protein levels and nerve damage in premature infants

FAN Haibo

Department of Laboratory Medicine， Jiamusi Maternal and Child Health Hospital in Heilongjiang Province， Jiamusi 154002， China

[Abstract] Objective To investigate the relationship between serum tau protein and S100 protein levels and nerve damage in preterm infants. Methods The clinical data of 80 preterm infants admitted to our hospital from February 2019 to February 2020 were collected. The research data of 40 preterm infants with brain injury were included in the observation group， and the research data of 40 preterm infants without brain injury were included in the control group. The neonatal behavioral neurological assessment（NBNA） score was recorded. The serum S100 protein and tau protein levels were detected. The correlation between the serum tau protein and S100 protein levels and nerve damage in premature infants was analyzed. Results The NBNA score in the observation group at 1 week after birth was （28.11±2.28） points， which was lower than （37.82±1.51） points in the control group， and the difference was significant （t=22.457， P=0.000）. The S100 protein level was （209.42±30.20） ng/L and tau protein level was （8.54±2.21） ng/L in the observation group at 1 week after birth， which were higher than those in the control group （[180.35±22.06] ng/L， [5.62±1.53] ng/L）， and the difference was statistically significant （P<0.05）. Pearson correlation analysis found that serum tau protein and S100 protein levels were negatively correlated with preterm infants′ NBNA score（r=-0.442， -0.557， P<0.05）. Conclusion Nerve damage in premature infants is related to serum tau protein and S100 protein levels. The serum test can evaluate brain damage and provide a reference for clinical diagnosis and treatment and prognosis evaluation.

[Key words] Nerve damage; Premature infants; Tau protein; S100 protein; Correlation

脑损伤是严重影响早产儿生存质量的疾病，与宫内窘迫、出生时缺氧缺血、内环境紊乱、血流动力学异常等因素有关，易影响智力及运动发育，甚至造成永久性神经功能缺陷，导致较高的致残率，不利于儿童健康生长发育[1-2]。因此，为减少认知、癫痫、脑瘫等发生风险，及时干预儿童中枢神经系统功能异常，早期明确早产儿脑损伤原因具有积极意义。而早期脑损伤早产儿临床症状不显著，无法准确评估病情，常通过影像超声技术，但检测费用较高，难以普及应用。有研究发现，早产儿脑损伤的发生发展与血清tau蛋白、S100蛋白密切相关，其中血清tau蛋白可反映脑损伤程度，其水平升高，提示存在脑损伤;而S100蛋白可作为脑组织损伤程度的评价指标，适用于诊断脑损伤并评估预后[3-4]。鉴于此，本研究收集我院2019年2月至2020年2月我院收治的早产儿80例临床资料，探讨血清S100蛋白、tau蛋白水平与早产儿神经损伤的相关性。……