银翘散加减联合盐酸左氧氟沙星对风热袭肺型肺炎患者IL-1、IL-6及细菌清除率的影响

王全周 庄秀梅

【摘要】 目的：探討银翘散加减联合盐酸左氧氟沙星对风热袭肺型肺炎患者白细胞介素-1（IL-1）、白细胞介素-6（IL-6）及细菌清除率的影响。方法：选择2017年2月-2019年12月本院收治的80例风热袭肺型肺炎患者为研究对象。按照随机数字表法分为观察组与对照组，每组40例。两组均接受常规治疗，另外，对照组给予盐酸左氧氟沙星治疗，观察组在对照组基础上加用银翘散加减治疗。比较两组患者治疗前后中医症状积分与炎症因子[C反应蛋白（CRP）、IL-1、IL-6]水平，同时统计两组患者细菌清除率与不良反应发生情况。结果：治疗前，两组患者中医症状积分、CRP、IL-1、IL-6水平比较，差异均无统计学意义（P>0.05）;治疗2周后，两组患者中医症状积分、CRP、IL-1、IL-6水平均较治疗前降低，且观察组均低于对照组，差异均有统计学意义（P<0.05）。观察组患者细菌清除率为92.50%，高于对照组的57.50%，差异有统计学意义（P<0.05）。两组患者不良反应发生率比较，差异无统计学意义（P>0.05）。结论：银翘散加减与盐酸左氧氟沙星联合治疗风热袭肺型肺炎患者具有显著的临床效果，不仅能够缓解患者临床症状，还可降低炎症因子水平，提高细菌清除率，且安全性较高。

【关键词】 肺炎 风热袭肺型 银翘散 盐酸左氧氟沙星 炎症因子 中医症状积分 细菌清除率

Effect of Yinqiaosan Plus or Minus Combined with Levofloxacin Hydrochloride on IL-1， IL-6 and Bacterial Clearance in Patients with Pneumonia Due to Wind-heat Attack/WANG Quanzhou， ZHUANG Xiumei. //Medical Innovation of China， 2021， 18（05）： 0-016

[Abstract] Objective： To investigate the effect of Yinqiaosan plus or minus combined with Levofloxacin Hydrochloride on interleukin-1 （IL-1）， interleukin-6 （IL-6） and bacterial clearance rate in patients with pneumonia due to wind-heat attack. Method： A total of 80 patients with wind-heat pneumonia admitted to our hospital from February 2017 to December 2019 were selected as the research objects. According to random number table method， they were divided into observation group and control group， 40 cases in each group. Both groups received conventional treatment， the control group was treated with Levofloxacin Hydrochloride， the observation group was treated with Yinqiaosan plus or minus on the basis of control group. The TCM symptom scores and the levels of inflammatory factors [C-reactive protein （CRP）， IL-1， IL-6] were compared between the two groups before and after treatment， and the bacterial clearance rate and the incidence of adverse reactions in the two groups were also counted. Result： Before treatment， there were no statistical significance in TCM symptom score， CRP， IL-1 and IL-6 levels between two groups （P>0.05）. After 2 weeks of treatment， TCM symptom scores， CRP， IL-1 and IL-6 levels in two groups were lower than those before treatment， and the observation group were lower than those of the control group， with statistical significance （P<0.05）. The bacterial clearance rate of observation group was 92.50%， which was higher than 57.50% of control group， the difference was statistically significant （P<0.05）. There was no statistical significance in the incidence of adverse reactions between two groups （P>0.05）. Conclusion： Yinqiaosan plus or minus combined with Levofloxacin Hydrochloride in the treatment of patients with wind-heat pneumonitis has significant clinical effects， which can not only alleviate the clinical symptoms of patients， but also reduce the level of inflammatory factors and improve the clearance rate of bacteria， with high safety.

[Key words] Pneumonia Wind-heat attack lung type Yinqiaosan Levofloxacin Hydrochloride Inflammatory factor TCM symptom score Bacterial clearance rate

First-authors address： Qingzhou Traditional Chinese Medicine Hospital of Weifang City， Qingzhou 262500， China

doi：10.3969/j.issn.1674-4985.2021.05.004

肺炎为临床发病率较高的一种呼吸系统疾病，其发病原因可能与细菌感染、病毒感染、真菌感染等引发的炎症反应存在一定关联[1-2]。目前，西医治疗该疾病主要以药物治疗为主，主要目的在于抑制炎症反应，提高细菌清除效果。盐酸左氧氟沙星为临床常见的抗生素，具有较强的广谱抗菌作用，常被临床用于治疗该疾病，虽具有一定的临床效果，但停药后病情易复发，降低临床治疗效果[3-4]。而中……