喉咽清口服液防治放射性口腔溃疡及咽炎的疗效研究

王贤文 唐纯玉 朱镇华 田道法 鄢宁 佘文雅

〔摘要〕 目的 觀察喉咽清口服液对放射性口腔溃疡及咽炎的防治效果。方法 将60例头颈部肿瘤初次放射治疗的患者随机分为观察组及对照组，每组30例，观察组含漱并口服喉咽清口服液，对照组含漱并口服康复新液。观察两组从放疗前3天至放疗结束的放射性黏膜损伤发生时的累积辐射剂量、口腔及咽部黏膜损伤程度、黏膜损伤高峰出现与持续时间、黏膜损伤愈合时间、局部疼痛程度视觉模拟评分（visal analogue scale， VAS）评分。结果 观察组患者开始出现放射性口腔溃疡及咽炎时的累积辐射剂量明显高于对照组，差异有统计学意义（P<0.05）;观察组患者黏膜损伤程度、黏膜损伤高峰持续时间、黏膜损伤愈合时间、局部疼痛程度VAS评分均明显低于对照组，差异有统计学意义（P<0.05）。结论 头颈肿瘤患者放疗期间配合喉咽清口服液含漱与口服能有效延缓放射性口腔溃疡及咽炎的发生，并缩短黏膜溃疡愈合时间，有效减轻临床不适症状，值得临床推广应用。

〔关键词〕 放射性口腔溃疡;放射性咽炎;头颈肿瘤;喉咽清口服液;累积辐射剂量;黏膜损伤程度;黏膜损伤愈合时间;疼痛视觉模拟评分

〔中图分类号〕R28           〔文献标志码〕B            〔文章编号〕doi：10.3969/j.issn.1674-070X.2021.05.022

Therapeutic Effect of Houyanqing Oral Liquid on Radiation Induced

Oral Ulcer and Pharyngitis

WANG Xianwen1 ， TANG Chunyu2，3， ZHU Zhenhua1， TIAN Daofa1， YAN Ning1， SHE Wenya1

（1. The First Affiliated Hospital of Hunan University of Chinese Medicine， Changsha， Hunan 410007， China; 2. Hunan Era Sunshine Pharmaceutical Co.，Ltd， Yongzhou， Hunan 425000， China; 3. Hunan Engineering Technology Research Center for

Anti-infection Traditional Chinese Medicine， Liuyang， Hunan 410300， China）

〔Abstract〕 Objective To investigate the therapeutic effect of a kind of herbal medicine preparation Houyanqing Oral Liquid （HYQOL） on radiation induced oral ulcer and pharyngitis. Methods 60 patients with head and neck tumor treated by radiotherapy were randomly divided into observation group and control group， with 30 patients in each group. The observation group was treated with gargle and oral HYQOL and the control group was treated with gargle and oral Kangfuxin Solution （KFXS）. The cumulative radiation dose of radiation induced mucosal injury， the severe degree of oral and pharyngeal mucosa injury induced by radiation， the appearing and lasting time of radiation induced mucosal injury at its peak phase， the healing time for the surface of damaged mucosa，the visal analogue scale （VAS） scores for local pain were observed in the two groups from 3 days before radiotherapy to the end of radiotherapy. Results The cumulative radiation dose at the beginning of radiation induced oral ulcer and pharyngitis in the observation group was significantly higher than that in the control group， with statistical significance （P<0.05）; the severe degree of radiation induced mucosal injury， the appearing and lasting time of radiation induced mucosal injury at its peak phase， the healing time for the surface of damaged mucosa， the VAS scores for local pain in the observation group were significantly lower than those in the control group， with statistical significance （P<0.05）. Conclusions Combined with HYQOL gargle and oral administration during radiotherapy for patients with head and neck tumor can effectively delay the occurrence of radioactive oral ulcer and pharyngitis， shorten the healing time of mucosal ulcer， and effectively reduce clinical discomfort symptoms， which is worthy of clinical promotion and application.

〔Keywords〕 radiation induced oral ulcer; radiation pharyngitis; head and neck tumor; Houyanqing Oral Liquid; cumulative radiation dose; the degree of mucosal injury; healing time of mucosal injury; visal analogue scale

放射治疗是头颈肿瘤（如鼻咽癌）常用的治疗手段之一，甚至是主要的治疗措施。但在放射治疗期间，放射性口腔溃疡及咽炎又是非常常见的并发症之一[1]。此类并发症给患者造成明显痛苦，甚至可能因为患者不能耐受而不得不中断放疗，严重影响了肿瘤的治疗成效。本文通过观察喉咽清口服液含漱加口服对头颈肿瘤放射治疗患者的放射性口腔溃疡及咽炎的防治效果，并与康复新液进行平行对比观察，现将结果报道如下。

1 资料与方法

1.1  一般资料

选取本院2018年1月至2019年6月收治的60例头颈恶性肿瘤（包括鼻咽癌、喉癌、舌癌、颊癌、口咽癌、下咽癌等）患者，按照随机数字表分为观察组和对照组，各30例。……