平消胶囊与卡培他滨联合治疗晚期乳腺癌的临床观察

李云霞

摘  要：目的  探讨平消胶囊+卡培他滨治疗晚期乳腺癌的作用。方法  选取2015年2月～2019年2月间阳谷县人民医院肿瘤血液科收治的80例晚期乳腺癌患者，采用随机数表法分组，两组均等。40例为对照组，使用卡培他滨，另40例为观察组，加用平消胶囊，对比两组用药情况。结果  观察组总缓解率与生活质量（物质生活、躯体功能、社会功能、心理功能）评分高于对照组，药物不良反应（胃肠道反应、失眠、骨髓抑制和皮肤瘙痒）发生率少于对照组，数据有差异（P<0.05）;两组用药前疼痛程度和体力状况对比无差异（P>0.05），观察组用药后疼痛感下降，体力上升，得分高于对照组，数据有差异（P<0.05）。 结论   晚期乳腺癌的治疗中使用平消胶囊和卡培他滨，效果明显，可缓解疼痛感，减少不良反应，可恢复体力，改善预后，有应用价值。

关键词：平消胶囊;卡培他滨;临床疗效;疼痛程度;体力状况;不良反应;生活质量

中图分类号：R683.42    文献标识码：A    文章编号：1009-8011（2021）-5-0007-04

Abstract： Objective  To explore the effect of Pingxiao capsule plus capecitabine in the treatment of advanced breast cancer. Methods  80 patients with advanced breast cancer admitted to the Department of Tumor Hematology， Yanggu County People's Hospital， Shandong Province from February 2015 to February 2019 were selected and divided into two groups by random number table method. The two groups were equal. 40 patients were treated with capecitabine as control group， and 40 patients were treated with Pingxiao capsule as observation group. Results  The total remission rate and quality of life（physical life， physical function， social function and psychological function）in the observation group were higher than those in the control group， and the adverse drug reactions（gastrointestinal reaction， insomnia， bone marrow suppression and pruritus）were less than those in the control group， with statistical difference（P<0.05）. There was no difference in pain degree and physical strength between the two groups before medication（P>0.05）. The pain degree and physical strength of the observation group decreased and increased after medication， and the score was higher than that of the control group， and the data were different（P<0.05）. Conclusion  In the treatment of advanced breast cancer， pingxiao capsule and capecitabine have obvious effects， can relieve pain， reduce adverse reactions， restore physical strength， improve prognosis， and have application value.

Keywords： Pingxiao capsule; Capecitabine; Clinical efficacy; Degree of pain; Physical condition; Adverse reactions; The quality of life

乳腺癌是婦科肿瘤病变的主要类型，多出现在围绝经期群体中。近些年来，其发病率和死亡率明显上升，对女性群体威胁较大。晚期乳腺癌可出现乳头凹陷、溢液、乳房肿块等表现，同时伴随难以忍受的疼痛感，可向淋巴结等身体各处转移，引发相应的症状表现，处理不及时，不但会导致患者生活质量下降，甚至可使得患者丧命。化疗可治疗此病，卡西他滨是治疗此病的常用药物，可通过消除病灶的方式来控制病情发展，但往往需长期用药方可获得较好的治疗效果，且易出现胃肠道反应、骨髓抑制等并发症，既影响药效，也可导致病情加重[1]。乳腺癌在中医中为“乳岩”等，由正气不足、肝气郁结、七情内伤所致，应以益气养血、疏肝解郁为原则进行治疗[2]。……