加温雾化治疗慢性阻塞性肺疾病的临床效果观察

【摘要】目的：观察加温雾化液雾化治疗在慢阻肺急性加重期的疗效。方法：选取2019年3月至2020年10月期间我院呼吸内科门诊及住院慢性阻塞性肺疾病急性加重期患者168例为研究对象。随机分组为观察组和对照组，每组84例。两组研究对象均采用氧气驱动雾化（6～8L/min）吸入0.9%氯化钠注射液2 mL+布地奈德混悬液2mg+硫酸特布他林雾化液5mg，2次/d，连续7 d。对照组雾化液温度为室温，观察组水浴加热至56℃雾化吸入10 min。两组均进入临床路径规范管理治疗。比较两组患者不良反应发生及慢阻肺急性加重控制时间间的差别。结果：观察组雾化发生不良反应次数低于对照组，同时慢阻肺急性加重期控制时间较对照组短（P<0.05）。结论：加温雾化治疗能够降低雾化治疗的不良反应，同时缩短慢阻肺急性加重期控制时间，具有临床应用价值。

【关键词】加温雾化；慢性阻塞性肺疾病；控制时间；不良反应

[中图分类号]R593.6 [文献标识码]A [文章编号]2096-5249（2021）13-0065-02

Observation on the clinical effect of heated nebulization in the treatment of chronic obstructive pulmonary disease

WANG Wei（Zhangye Second People’s Hospital， Zhangye Gansu 734000， China）

[Abstract] Objective： To observe the curative effect of heated nebulization liquid nebulization treatment in the acute exacerbation of chronic obstructive pulmonary disease. Method： Selected 168 patients with acute exacerbation of chronic obstructive pulmonary disease in our hospital from March 2019 to October 2020. Randomly group， 84 cases in observation group and control group. Both groups of subjects used oxygen-driven nebulization （6～8L/min） to inhale 0.9% sodium chloride injection 2 mL+ budesonide suspension 2mg+ terbutaline sulfate nebulization solution 5mg， 2 times a day， 7 consecutive day. The temperature of the atomization liquid in the control group was room temperature， and the water bath in the observation group was heated to 56°C for 10 minutes. Both groups entered the clinical pathway for standardized management and treatment. The difference between the occurrence of adverse reactions and the control time of COPD exacerbation between the two groups of patients was compared. Results： The number of adverse reactions of nebulization in the observation group was lower than that in the control group， and the control period of acute exacerbation of COPD was shorter than that in the control group （P<0.05）. Conclusion： Heated nebulization therapy can reduce the adverse effects of nebulization therapy and shorten the control time of COPD acute exacerbation， which has clinical application value.

[Key words] Heating and atomization； Chronic obstructive pulmonary disease； Control time； Adverse reactions

眾所周知，慢性阻塞性肺疾病急性加重比例高，死亡率也高，每年每个患者发生急性加重约0.5～3.5次[1]。布地奈德联合特布他林雾化吸入治疗慢性阻塞性肺疾病急性加重期效果肯定[2]，发现雾化吸入糖皮质激素、支气管扩张剂、祛痰药物等成为其主要治疗方法之一。雾化吸入也体现了气道疾病的精准治疗，因为雾化吸入治疗，可使药物直接作用于下呼吸道，局部吸收，迅速起效，同时降低全身不良反应。但也常常出现部分患者雾化治疗后慢阻肺急性加重没有有效控制，反而诱发其进一步加重，甚至出现胸闷、心慌、咳嗽、喘息等症状而中断治疗。……