血栓通注射液对不稳定性心绞痛患者血清IL—6及MMP—2的影响

王泰然 马巍

[摘要] 目的 观察血栓通注射液对不稳定性心绞痛患者的临床疗效，并探讨其对白细胞介素-6（IL-6）和基质金属蛋白酶-2（MMP-2）水平的影响及其治疗不稳定性心绞痛的可能的作用机制。 方法 选取2017年1～10月在邯郸市中心医院心内科住院的不稳定性心绞痛患者120 例，按随机数字表法分为对照组和治疗组，每组60例。对照组给予西医常规治疗，治疗组在对照组治疗基础上加用血栓通注射液治疗，连续应用14 d。观察两组患者心绞痛、心电图疗效及治疗前后血清IL-6和MMP-2水平变化。 结果 治疗组与对照组治疗后心绞痛和心电图疗效均明显改善，前者疗效明显优于后者（P < 0.05），两组患者血清IL-6和MMP-2水平与治疗前比较均明显下降（P < 0.05），治療后治疗组患者血清IL-6和MMP-2水平均明显低于对照组（P < 0.05）。 结论 对于不稳定性心绞痛患者，在常规治疗基础上加用血栓通注射液疗效确切，其作用基质可能与其显著降低炎性因子IL-6 和MMP-2水平，抑制炎性反应有关。

[关键词] 不稳定性心绞痛；血栓通注射液；白细胞介素-6；基质金属蛋白酶-9

[中图分类号] R541.1 [文献标识码] A [文章编号] 1673-7210（2018）05（c）-0127-04

Influence of Xueshuantong Injection on serum IL-6 and MMP-2 in patients with unstable angina pectoris

WANG Tairan1 MA Wei2

1.Department of Cardiology， Handan Central Hospital， Hebei Province， Handan 056001， China； 2.Department of Gynaecology and Obstetrics， Jizhong Energy Fengfeng Group Hospital， Hebei Province， Handan 056200， China

[Abstract] Objective To observe the effect of Xueshuantong Injection on soluble interlekin-6 （IL-6） and matrix metalloproteinase-2 （MMP-9） in patients with unstable angina pectoris and its potential mechanism. Methods From January 2017 to October 2017， 120 patients treated in the Department of Cardiology， Handan Central Hospital were divided into control group （n=60） and treatment group （n=60） by random number table. Patients in the control group were treated with routine treatment， and the patients in the treatment group were treated with Xueshuantong Injection based on the control group， they were treated for 14 days. The effects of unstable angina pectoris and electrocardiogram curative were observed. The levels of serum IL-6 and MMP-2 were measured before and after treatment. Results After treatment， the effects of unstable angina pectoris and electrocardiogram curative in the treatment group were significantly higher than those in the control group （P < 0.05）. The levels of serum IL-6 and MMP-2 in the two groups were significantly lower than before treatment （P < 0.05）. The levels of serum IL-6 and MMP-2 in the treatment group were lower than those in the control group after treatment （P < 0.05）. Conclusion Xueshuantong Injection has effect in patients with unstable angina pectoris， which can reduce the levels of serum IL-6 and MMP-2， and inhibit inflammatory reaction.

[Key words] Unstable angina pectoris； Xueshuantong Injection； Interlekin-6； Matrix metalloproteinase-2

不稳定性心绞痛（unstable angina pectoris，UAP）是介于急性心肌梗死和稳定性心绞痛之间的临床冠脉综合征[1]。症状反复发作，最终可发展为急性心肌梗死，甚至导致心律失常而引起患者猝死。其病理基础为冠状动脉粥样硬化（atherosclerosis，AS）斑块的形成和进展。越来越多的证据表明动脉粥样硬化是一种炎性反应，炎性因子的过表达与AS的发生与发展密切相关[2]。白细胞介素-6（interlekin-6，IL-6）是机体炎性反应及病理生理过程中的一种重要介质，又被成为多效能前炎性细胞因子，在炎性反应中扮演着中枢性调节者的角色。IL-6在冠心病发病的炎性反应中起着重要作用，通过多种途径促进的动脉粥样硬化斑块的形成并导致斑块破裂，导致急性冠脉综合征的发生与进展[3]。……