丹红注射液辅助化疗对乳腺癌患者Caspase-3表达及生存质量的影响

李懿放

【摘要】 目的：探討丹红注射液辅助化疗对乳腺癌患者Caspase-3表达及生存质量的影响。方法：选取2017年10月-2020年10月本院收治的60例乳腺癌患者，根据随机数字表法将其分为观察组和对照组，每组30例。对照组采用紫杉醇+顺铂化疗，观察组在对照组基础上加用丹红注射液治疗。比较两组治疗总有效率、疾病控制率及胃肠道毒副作用发生情况;比较两组治疗前后Caspase-3表达情况和生活质量评分。结果：观察组疾病控制率为96.67%，高于对照组的83.33%，但差异无统计学意义（P>0.05）。观察组总有效率为83.33%，高于对照组的60.00%，差异有统计学意义（P<0.05）。治疗前，两组Caspase-3表达水平比较，差异无统计学意义（P>0.05）;治疗后，观察组Caspase-3表达水平高于对照组，差异有统计学意义（P<0.05）。观察组腹泻或腹胀、乏力或消瘦、恶心或呕吐以及纳差发生率均低于对照组，差异均有统计学意义（P<0.05）。治疗前，两组精神健康、情感职能、社会功能、精力、一般健康状况、躯体疼痛、生理职能、生理功能评分比较，差异均无统计学意义（P>0.05）;治疗后，观察组精神健康、情感职能、社会功能、精力、一般健康状况、躯体疼痛、生理职能、生理功能评分均高于对照组，差异均有统计学意义（P<0.05）。结论：应用丹红注射液辅助化疗能够提升乳腺癌的治疗效率，降低Caspase-3水平，减少化疗对患者胃肠道带来的毒副作用，提升患者生存质量，值得临床应用推广。

【关键词】 丹红注射液 辅助化疗 乳腺癌

Effect of Danhong Injection Adjuvant Chemotherapy on the Expression of Caspase-3 and Quality of Life in Patients with Breast Cancer/LI Yifang. //Medical Innovation of China， 2021， 18（30）： 0-033

[Abstract] Objective： To investigate the effect of Danhong Injection adjuvant chemotherapy on the expression of Caspase-3 and quality of life in patients with breast cancer. Method： A total of 60 breast cancer patients admitted to our hospital from October 2017 to October 2020 were selected， they were divide into observation group and control group according to the random number table method， 30 cases in each group. The control group was treated with Paclitaxel and Cisplatin， and the observation group was treated with Danhong Injection on the basis of the control group. The total effective rate， disease control rate and occurrence of gastrointestinal toxicity and side effects were compared between two groups; Caspase-3 expression and quality of life scores before and after treatment were compared between two groups. Result： The disease control rate of the observation group was 96.67%， which was higher than 83.33% of the control group， but the difference was not statistically significant （P>0.05）. The total effective rate of the observation group was 83.33%， which was higher than 60.00% of the control group， the difference was statistically significant （P<0.05）. Before treatment， there was no significant difference in Caspase-3 expression between two groups （P>0.05）; after treatment， the Caspase-3 expression of the observation group was higher than that of the control group， the difference was statistically significant （P<0.05）. The incidences of diarrhea or abdominal distension， fatigue or emaciation， nausea or vomiting and poor appetite of the observation group were lower than those of the control group， the differences were statistically significant （P<0.05）. Before treatment， there were no significant differences in mental health， emotional function， social function， energy， general health， physical pain， physiological function and physiological function scores between two groups （P>0.05）; after treatment， the mental health， emotional function， social function， energy， general health， physical pain， physiological function and physiological function scores of the observation group were higher than those of the control group， the differences were statistically significant （P<0.05）. Conclusion： Danhong Injection adjuvant chemotherapy can improve the treatment efficiency of breast cancer， reduce Caspase-3， reduce the side effects of chemotherapy on gastrointestinal tract， and improve the quality of life of patients， which is worthy of clinical application and promotion.

[Key words] Danhong Injection Adjuvant chemotherapy Breast cancer

First-authors address： Shenyang Hospital of Traditional Chinese Medicine， Shenyang 110003， China

doi：10.3969/j.issn.1674-4985.2021.30.007

乳腺癌发病率逐年升高，已成为我国女性最常见的恶性肿瘤之一。当前乳腺癌发病的原因与乳腺癌家族史和易感基因、放射线环境、高脂肪饮食以及体内的雌激素水平等有着很大关系。其并发症多、危险性大，预后差，早期临床症状并不明显，大多数患者出现乳房皮肤改变、引流区淋巴结肿大时已是疾病晚期[1-2]。临床上对晚期乳腺癌患者一般采取手术、化疗和放疗等综合治疗方式，治疗效果较好，能够让患者保持稳定状态。但是无论是手术治疗还是放化疗，患者的术后复发率均较高，而且化疗的毒副作用会增加患者的痛苦，增加了患者不良反应而且对癌细胞的转移和增殖抑制效果有限。随着……