血清CA125和铁蛋白联合检测对上皮性卵巢癌的诊断价值

刘琛姝

【摘要】 目的：探讨血清CA125和铁蛋白联合检测对上皮性卵巢癌的诊断价值。方法：选取2015年1月-2019年8月来本院就诊的30例上皮性卵巢癌患者为A组，30例卵巢良性病变患者为B组，30例同期健康体检者为对照组。检测三组血清CA125和铁蛋白水平。分析血清CA125和铁蛋白的关系。分析血清CA125和铁蛋白联合检测对上皮性卵巢癌的诊断价值。结果：A、B组CA125水平均高于对照组，且A组高于B组，差异均有统计学意义（P<0.05）。A组血清铁蛋白水平高于对照组和B组，差异均有统计学意义（P<0.05）。B组血清铁蛋白虽高于对照组，但差异无统计学意义（P>0.05）。三组CA125及血清铁蛋白比较，差异均有统计学意义（P<0.05）。CA125和血清欠揍蛋白呈正相关（r=0.889，P<0.05）。血清CA125单因素检测最佳阈值为107.21 U/mL，AUC为0.828[P=0.002，95%CI（0.734，0.922）]，敏感度100%，特异度64.35%;血清铁蛋白单因素检测最佳阈值为199.21 ng/mL，AUC为0.830[P=0.013，95%CI（0.737，0.924）]，敏感度77.27%，特异度78.38%。联合检测中，其AUC为0.953[P=0.011，95%CI（0.909，0.998）]，敏感度91.35%，特异度93.27%。结论：上皮性卵巢癌患者血清CA125与铁蛋白均升高，血清CA125和铁蛋白联合检测較单因素检测诊断价值更佳，值得临床推广。

【关键词】 血清CA125 铁蛋白 上皮性卵巢癌

Diagnostic Value of Combined Detection of Serum CA125 and Ferritin in Epithelial Ovarian Cancer/LIU Chenshu. //Medical Innovation of China， 2021， 18（30）： -174

[Abstract] Objective： To investigate the diagnostic value of combined detection of serum CA125 and ferritin in epithelial ovarian cancer. Method： 30 patients with epithelial ovarian cancer who came to our hospital from January 2015 to August 2019 were selected as group A， 30 patients with benign ovarian disease as group B， and 30 healthy subjects during the same period were selected as control group. Serum CA125 and ferritin levels in three groups were detected. The relationship between serum CA125 and ferritin was analyzed. The diagnostic value of combined detection of serum CA125 and ferritin in epithelial ovarian cancer was analyzed. Result： CA125 levels of the group A and group B were higher than that of the control group， and that of the group A was higher than that of the group B， the differences were statistically significant （P<0.05）. The serum ferrictin level of the group A was higher than that of the control group and group B， the differences were statistically significant（P<0.05）. Serum ferritin of the group B was higher than that of the control group， but the difference was not statistically significant （P>0.05）. There were statistically significant differences in CA125 and serum ferric protein among three groups （P<0.05）. CA125 was positively correlated with serum ferric protein （r=0.889， P<0.05）. The optimal threshold of serum CA125 was 107.21 U/mL， AUC was 0.828 [P=0.002， 95%CI （0.734， 0.922）]， sensitivity was 100%， specificity was 64.35%. The optimal threshold of serum ferritin single factor detection was 199.21 ng/mL， AUC was 0.830 [P=0.013， 95%CI （0.737， 0.924）]， sensitivity was 77.27%， specificity was 78.38%. The optimal threshold of combined detection， AUC was 0.953 [P=0.011， 95%CI （0.909， 0.998）]， sensitivity was 91.35%， specificity was 93.27%. Conclusion： Serum CA125 and ferritin in patients with epithelial ovarian cancer were increased， the combined detection of serum CA125 and ferritin have better diagnostic value than single factor detection， which is worthy of clinical promotion.

[Key words] Serum CA125 Ferritin Epithelial ovarian cancer

First-author’s address： Xiaolan Hospital Affiliated to Southern Medical University， Zhongshan 528415， China

doi：10.3969/j.issn.1674-4985.2021.30.041

上皮性卵巢癌在卵巢恶性肿瘤中占比高达70%，这种类型的恶性肿瘤早期大多无典型的临床表现，等到患者发病时，病情基本已进展到了疾病晚期。具体病理表现如：腹腔内种植、肝实质或胸腔、颅内转移等，这也是造成此类卵巢癌患者死亡率高的主要原因[1-2]。如今临床上认可度较高的诊断早期恶性肿瘤的重要指标是肿瘤标志物，其中以糖类抗原125（carbohydrate anrigen 125，CA125）在临床上应用较为广泛。经研究发现，CA125对卵巢癌的敏感性极高，但其特异性却差强人意[3-4]。……