姜酚抗肿瘤作用机制的研究进展

董文南 李克招 柴尧 左丽平 郑洋滨

【摘要】 生姜一直是被广泛使用的天然药物之一，鲜姜中的主要功能成分姜酚，是一系列具有的酚酮官能团，烷基侧链连接不同的碳原子个数的同系物的统称。姜酚作为活性多样的天然药物，由于其安全、低毒的优势成为近几年关注的热点，尤其是其抗肿瘤活性获得了越来越多的关注。随着对姜酚药理作用的深入研究，已证实姜酚在抗肿瘤、抗炎、抗病毒、止呕等方面具有重要的应用价值。药理学研究表明，姜酚主要通过抑制肿瘤细胞增殖，诱导肿瘤细胞凋亡，调控基因和蛋白表达，调节信号通路，肿瘤细胞周期阻滞，受体抑制及其他等方面发挥抗肿瘤作用。为加强姜酚的抗肿瘤活性临床研究，扩大其应用前景，本文对近年来国内外姜酚相关文献进行了整理归纳，对其抗肿瘤机制的研究进展及其在临床上的应用做一综述。

【关键词】 姜酚 抗肿瘤 作用机制 研究进展

Recearch Progress on Anti-tumor Mechanisms of Gingerol/DONG Wennan， LI Kezhao， CHAI Yao， ZUO Liping， ZHENG Yangbin. //Medical Innovation of China， 2021， 18（30）： -184

[Abstract] Ginger is one of the most widely used natural medicines， gingerols are the main functional component in fresh ginger which have a series of phenol acetone functional groups， and a general term for alkyl side chains connecting different numbers of carbon atoms. As a natural drug with various activities， gingerol has become a hot spot in recent years because of its safety and low toxicity， especially its antitumor activity has attracted more and more attention. With the deepening of research of its pharmacological effect， it has been proved that gingerol has important application value in anti-tumor， anti-inflammation， anti-virus， as well as anti-vomiting. The pharmacology studies showed that gingerol plays an important role on anti-tumor by inhibiting tumor cell proliferation， inducing tumor cell apoptosis， regulate gene and protein expression， dominating signaling pathway， blocking cell growth cycle， receptor inhibition and other aspects. This article summarizes the related literature at home and abroad on gingerol in recent years. In order to strengthen the clinical research on the anti-tumor activity of gingerol， and expand its application prospects， this review focuses on anti-tumor mechanism and clinical application of gingerol.

[Key words] Gingerol Anti-tumor Mechanism of action Research progress

First-author’s address： Jiangxi Institute for Drug Control， NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine， Jiangxi Province Engineering Research Center of Drug and Medical Device Quality， Nanchang 330029， China

doi：10.3969/j.issn.1674-4985.2021.30.043

由于中国人口的老龄化持续加重，癌症的发病数量和种类也越来越多，成为导致人类死亡的重要原因[1]，从天然的植物药中寻找具有抗肿瘤作用的有效成分，作为化学药物抗肿瘤的重要补充手段，一直是中药研究者关注的焦点。

姜（Zingiber officinale Rosc.）通称生姜，为姜科植物姜的鲜嫩茎，为多年生草本宿根植物。有发表、散寒、止呕、化痰等功效。因其“可蔬、可和、可果、可药，其利之博矣”，《神龙本草经》将其列为上品。《本草纲目》中记载：生姜气味辛、微温、无毒，通神明，经五脏除风邪寒热，伤寒头痛鼻塞，去痰下气[2]。……