透邪解毒方治疗胃肠湿热型腹泻型肠易激综合征的临床观察

凌家生 谭文涛 林浩 梁瑞华

【摘要】 目的：探讨透邪解毒方治疗胃肠湿热型腹泻型肠易激综合征的临床效果。方法：选取2019年2月-2021年7月本院收治的110例胃肠湿热型腹泻型肠易激综合征患者，按照随机数字表法将其分为观察组和对照组，每组55例。对照组给予常规西药治疗，观察组在对照组的基础上加用透邪解毒方。比较两组临床疗效，治疗前后中医症状评分、炎性因子水平、IBS-BSS和IBS-QOL评分。结果：观察组总有效率为90.91%，高于对照组的76.36%，差异有统计学意义（P<0.05）。治疗前，两组大便性状、频次、腹痛腹胀评分比较，差异均无统计学意义（P>0.05）;治疗后，两组大便性状、频次、腹痛腹胀评分均低于治疗前，且观察组均低于观察组，差异均有统计学意义（P<0.05）。治疗前，两组IL-10、TNF-α比较，差异均无统计学意义（P>0.05）;治疗后，两组IL-10、TNF-α均优于治疗前，且观察组均优于对照组，差异均有统计学意义（P<0.05）。治疗前，两组IBS-BSS、IBS-QOL评分比较，差异均无统计学意义（P>0.05）;治疗后，两组IBS-BSS、IBS-QOL評分均优于治疗前，且观察组均优于对照组，差异均有统计学意义（P<0.05）。结论：透邪解毒方辅助西药治疗胃肠湿热型腹泻型肠易激综合征可提高疗效，改善症状及生活质量，降低炎症反应，值得推广。

【关键词】 透邪解毒方 胃肠湿热型 腹泻型 肠易激综合征

Clinical Observation on Treatment of Gastrointestinal Damp-heat Syndrome Diarrhea-type Irritable Bowel Syndrome with Touxie Jiedu Decoction/LING Jiasheng， TAN Wentao， LIN Hao， LIANG Ruihua. //Medical Innovation of China， 2021， 18（30）： 086-090

[Abstract] Objective： To explore and analyze the clinical effects on treatment of gastrointestinal damp-heat syndrome diarrhea-type irritable bowel syndrome with Touxie Jiedu Decoction. Method： A total of 110 patients with gastrointestinal damp-heat syndrome diarrhea-type irritable bowel syndrome admitted to our hospital from February 2019 to July 2021 were selected， and they were divided into observation group and control group according to random number table method， 55 cases in each group. The control group was treated with conventional treatment of western medicine， and the observation group was treated with Touxie Jiedu Decoction on the basis of the control group. The clinical efficacy was compared between two groups， TCM symptom score， inflammatory factor， IBS-BSS and IBS-QOL scores before and after treatment were compared between two groups. Result： The total effective rate of observation group was 90.91%， which was higher than 76.36% of control group， the difference was statistically significant （P<0.05）. Before treatment， there were no significant differences in stool characteristics， frequency， abdominal pain and abdominal distension scores between two groups （P>0.05）; after treatment， stool characteristics， frequency and abdominal pain and abdominal distension scores of both groups were lower than those before treatment， and those of the observation group were lower than those of the control group， the differences were statistically significant （P<0.05）. Before treatment， there were no significant differences in IL-10 and TNF-α between two groups （P>0.05）; after treatment， IL-10 and TNF-α of both groups were better than those before treatment， and those of the observation group were better than those of the control group， the differences were statistically significant （P<0.05）. Before treatment， there were no significant differences in IBS-BSS and IBS-QOL scores between two groups （P>0.05）; after treatment， IBS-BSS and IBS-QOL scores of both groups were better than those before treatment， and those of the observation group were better than those of the control group， the differences were statistically significant （P<0.05）. Conclusion： Touxie Jiedu Decoction assisted western medicine in the treatment of gastrointestinal damp-heat syndrome diarrhea-type irritable bowel syndrome can improve the clinical efficacy， improve the clinical symptoms and quality of life， and reduce the inflammatory reaction， which is worthy of promotion.

[Key words] Touxie Jiedu Decoction Gastrointestinal damp-heat syndrome Diarrhea type Irritable bowel syndrome

First-author’s address： Huizhou Hospital of Traditional Chinese Medicine， Huizhou 516001， China

doi：10.3969/j.issn.1674-4985.2021.30.021

肠易激综合征是临床上常见的胃肠道疾病，常见的类型有腹泻型、便秘型、混合型等，患者常见的临床症状包括腹痛、腹泻、排便异常，持续、间歇性的肠道功能紊乱，可合并消化道、心脏、泌尿系统症状，部分患者还伴有焦虑、抑郁等负性心理情绪，对患者的身心健康造成严重影响[1-2]。……