妊娠期糖尿病患者血清网膜素与FPG、FINS及胰岛素抵抗指数的相关性分析

李葵琴

【摘要】 目的：分析妊娠期糖尿病（GDM）患者血清網膜素（Omentin）与FPG、FINS及（HOMA-IR）的相关性。方法：选取2018年3月-2020年3月本院收治的孕前肥胖GDM患者60例作为研究1组，同时选择本院收治的孕前非肥胖GDM患者60例作为研究2组，同时选取同时间段在本院产检的健康妊娠期女性60例作为对照组。比较三组血压、血脂、血清Omentin、空腹血糖（FPG）、空腹胰岛素（FINS）、HOMA-IR情况，采用Pearson相关性分析Omentin与FPG、FINS、HOMA-IR的相关性。结果：三组收缩压、舒张压、LDL-C、TG、TC、HDL-C比较，差异均有统计学意义（P<0.05）;研究1、2组收缩压、舒张压及TC比较，差异均无统计学意义（P>0.05）;研究1组LDL-C、TG及HDL-C水平均高于研究2组（P<0.05）。研究1、2组Omentin均低于对照组，FPG、FINS、HOMA-IR均高于对照组，差异均有统计学意义（P<0.05）。Pearson相关性分析结果显示：Omentin与FPG、FINS、HOMA-IR均呈负相关（r=-0.438、-0.579、-0.755，P<0.05）。结论：GDM患者血清Omentin与FPG、FINS及HOMA-IR的相关性分析中，GDM患者存在明显的胰岛素抵抗、脂代谢异常、糖代谢异常症状，且Omentin水平明显降低，伴肥胖的GDM患者胰岛素抵抗程度、代谢异常程度更高，Omentin水平更低。Omentin水平降低可能在GDM发生、发展中发挥了作用。

【关键词】 妊娠期糖尿病 血清网膜素 空腹血糖 空腹胰岛素 胰岛素抵抗指数

Correlation Analysis of Serum Omentin and FPG， FINS， Insulin Resistance Index in Patients with Gestational Diabetes Mellitus/LI Kuiqin. //Medical Innovation of China， 2021， 18（30）： -162

[Abstract] Objective： To analyze the correlation of serum Omentin and FPG， FINS and insulin resistance index （HOMA-IR） in patients with gestational diabetes mellitus （GDM）. Method： A total of 60 pre pregnancy obese GDM patients treated in our hospital from March 2018 to March 2020 were selected as the study 1 group ， 60 pre pregnancy non obese GDM patients treated in our hospital were selected as the study 2 group， and 60 healthy pregnant women examined in our hospital at the same time were selected as the control group. The blood pressure， blood lipid， serum Omentin， fasting plasma glucose （FPG）， fasting insulin （FINS） and HOMA-IR of three groups were compared， Pearson correlation analysis was used to analyze the correlation between Omentin and FPG， FINS and HOMA-IR. Result： Comparison of systolic blood pressure， diastolic blood pressure， LDL-C， TG， TC and HDL-C among the three groups， the differences were statistically significant （P<0.05）; there were no significant differences in systolic blood pressure， diastolic blood pressure and TC between the study 1 and 2 groups （P>0.05）; the levels of LDL-C， TG and HDL-C in the study 1 group were higher than those in the study 2 group （P<0.05）. The Omentin in the study 1 and 2 groups were lower than that in the control group， and FPG， FINS and HOMA-IR were higher than those in the control group， the differences were statistically significant （P<0.05）. Pearson correlation analysis showed that Omentin were negatively correlated with FPG， FINS and HOMA-IR （r=-0.438， -0.579， -0.755， P<0.05）. Conclusion： The correlation analysis between serum Omentin and FPG， FINS， HOMA-IR in patients with GDM， GDM patients have obvious symptoms of insulin resistance， abnormal lipid metabolism and abnormal glucose metabolism， and the level of Omentin is significantly reduced， GDM patients with obesity have higher degree of insulin resistance， abnormal metabolism and lower level of Omentin. The decrease of Omentin level may play a role in the occurrence and development of GDM.

[Key words] Gestational diabetes mellitus Serum omentin Fasting plasma glucose Fasting insulin Insulin resistance index

First-author’s address： Shangrao Maternal and Child Health Hospital， Shangrao 334000， China

doi：10.3969/j.issn.1674-4985.2021.30.038

妊娠期糖尿病（GDM）是妊娠期间发生率较高的疾病，主要是由于糖耐量异常引发的内分泌代谢疾病，是一种比较特殊的糖尿病[1]。临床大量研究显示，肥胖与许多不良妊娠结局有很大的关系，会使巨大儿、GDM、妊娠期高血压疾病的发生率显著提高，会对母婴安全造成威胁[2-3]。脂肪组织分泌的多种脂肪因子会参与胰岛素抵抗调节，与糖尿病、高血压等疾病的发生存在密切的联系[4-5]。网膜素（Omentin）是近几年临床新发现的一种脂肪因子，会改善胰岛素抵抗，推测血清Omentin水平降低是导致糖尿病发生发展、胰岛素抵抗、代谢综合征发生发展的重要原因，但是临床关于Omentin与GDM的相关报道较少[6]。……