采用引火归元法治疗虚阳上越证型乳腺癌患者化疗相关口腔黏膜炎的效果评价

叶津津 黄晓莉

[摘要] 目的 探討虚阳上越型乳腺癌患者化疗后发生口腔黏膜炎采用引火归元法治疗的临床疗效。 方法 选择本院2017年1月至2019年1月收治的50例虚阳上越型乳腺癌化疗后发生口腔黏膜炎患者，随机将患者分为对照组（n=25）与研究组（n=25）。对照组患者均予以庆大霉素含漱液漱口结合服用维生素B2片治疗，研究组患者采用中药引火归元疗法治疗。对比分析两组患者治疗前后的口腔黏膜炎分级情况、VAS疼痛评分、溃疡发作时间、全身症状表现及临床疗效情况。 结果 两组患者治疗前口腔黏膜炎分级情况比较，差异无统计学意义（P>0.05）;研究组治疗后口腔黏膜炎分级情况低于对照组（P<0.05）;研究组治疗后VAS疼痛评分低于对照组（P<0.05）;两组患者治疗后溃疡发作时间比较，差异无统计学意义（P>0.05）;研究组治疗后全身症状评分低于对照组（P<0.05）;两组患者治疗前后白细胞总数、中性粒细胞组间比较，差异无统计学意义（P>0.05），治疗后两组患者白细胞总数、中性粒细胞均高于治疗前，差异有统计学意义（P<0.05）;研究组患者治疗后总有效率高于对照组，差异有统计学意义（P<0.05）;两组患者治疗后均未发生药物过敏反应或其他不良反应。 结论 临床针对虚阳上越证型乳腺癌患者化疗治疗相关口腔黏膜炎疾病，采用引火归元法治疗疗效相比常规西医治疗更明确，患者治疗后全身症状得到更有效改善，且该治疗方法安全性高，值得临床推广应用。

[关键词] 虚阳上越型乳腺癌;化疗治疗;口腔黏膜炎;引火归元法;临床疗效;安全性

[Abstract] Objective To explore and analyze the clinical efficacy of chemotherapy-related oral mucositis in patients with breast cancer of upward dispersion of deficient Yang treated by guiding fire to origin. Methods A total of 50 patients with oral mucositis caused by chemotherapy of breast cancer of upward dispersion of deficient Yang admitted to our hospital from January 2017 to January 2019 were randomLy divided into the control group（n=25） and the research group（n=25）. Patients in the control group were treated with gentamicin gargle combined with vitamin B2 tablets， while patients in the study group were treated with traditional Chinese medicine of guiding fire to origin therapy. The classification of oral mucositis，VAS pain score， ulcer attack time，systemic symptoms and clinical efficacy of the two groups at baseline and post-treatment were compared and analyzed. Results There was no significant difference in the classification of oral mucositis between the two groups at baseline（P>0.05）. The classification of oral mucositis in the study group was significantly lower than that in the control group（P<0.05）. The VAS pain score in the study group was significantly lower than that in the control group（P<0.05）. There was no significant difference in ulcer attack time between the two groups after treatment（P>0.05）. After treatment，the systemic symptom score in the study group was significantly lower than that in the control group（P<0.05）. There was no significant difference in the total number of leukocytes and neutrophils between the two groups at baseline and post-treatment（P>0.05）. The total number of leukocytes and neutrophils in the two groups after treatment were significantly higher than baseline（P<0.05）. The total effective rate of the study group was significantly higher than that of the control group（P<0.05）. No drug allergy or other adverse reactions occurred after treatment in the two groups of patients. Conclusion The clinical curative effect of guiding fire to origin method for chemotherapy-related oral mucositis diseases of breast cancer patients with upward dispersion of deficient Yang is more definite than that of conventional western medicine treatment， the systemic symptoms of the patients are improved more effectively after treatment， and the treatment method has high safety and is worthy of clinical promotion and application.

[Key words] Breast cancer of upward dispersion of deficient Yang; Chemotherapy; Oral mucositis; Guiding fire to origin method; Clinical efficacy; Safety

乳腺癌是女性临床常见的一类恶性肿瘤疾病，乳腺癌在全癌死因当中排第5位。目前，针对于乳腺癌患者的临床治疗主要采取化疗治疗方法，该方法为乳腺癌综合治疗当中的一个重要疗法[1-2]。化疗治疗可降低乳腺癌患者复发率及肿瘤的转移率，从而延长患者生存时间[3]。然而，肿瘤细胞代谢与机体内其他正常细胞无本质的差别，在进行化疗治疗过程中，化疗药物缺乏对肿瘤细胞的选择特异性，导致在杀伤肿瘤细胞的同时，对患者身体的其他部位组织细胞产生毒性作用，引发其他药物副反应[4-5]。口腔……