金红 郑熙圆 陈颖 孙振 张琪 张敏
【摘 要】 抑郁症(Depression)为临床常见的精神障碍疾病,针灸治疗本病在临床和机制研究上均有良好进展。“百会”、“印堂”为治疗抑郁症的重要腧穴,目前尚无文献对其进行系统的整理分析。通过查阅分析百会、印堂治疗抑郁症的理论、临床及机制研究方面的文献发现:百会、印堂治疗抑郁症为督脉论治思想的体现,其通过调节神经递质水平、干预相关信号通路发挥抗抑郁作用,并在核心及躯体症状、原发及继发性抑郁的治疗中获效良好。
【关键词】 抑郁症;督脉;神经递质;信号通路;躯体症状
【中图分类号】R246.6 【文献标志码】 A 【文章编号】1007-8517(2021)11-0062-05
Abstract:Depression is a common clinical mental disorder, but the acupuncture treatment of this disease has obtained good progress in clinical and mechanism research.In fact, “Baihui(GV20)” and “Yintang(GV29)” are important acupoints for the treatment of depression, but there is no literature investigating them systematically.By consulting and analyzing the existing literature on the theory, clinical and mechanism research of Baihui and Yintangs treatment of depression, we found that: Baihui and Yintangs treatment of depression is a manifestation of Governor Channels ideology, which exerts antidepressant effects by regulating neurotransmitter levels and by intervening in related signal pathways, and it has been effective against the treatment of core and somatic symptoms, primary and secondary depression.
Keywords:Depression;Governor Channel;Neurotransmitters;Signaling Pathway;Somatic Symptoms
抑郁症是以显著而持久的情绪低落为主要症状的临床常见精神疾病,全球发病率为4.4%[1],不仅社会危险性高,病因复杂,且严重影响躯体症状及神经功能,其临床及机制研究成为精神疾病领域的研究重心。针灸治疗抑郁症历史已久,经验丰富,其疗效已在大量科学研究中得到证实,在抑郁症治疗中占有举足轻重的地位。1984年罗和春首次采用电针百会、印堂治疗抑郁症,开创了现代督脉论治抑郁症的先河,此后的三十多年成为了督脉治疗抑郁症的鼎盛期。有研究[2]對针灸治疗抑郁症的选穴处方规律进行分析后发现百会、印堂的被选择频率最高,可见其地位何等重要。因此,为系统了解百会、印堂在抑郁症治疗中的研究情况,本文用计算机检索方式,以“针刺、电针、百会、印堂、督脉、抑郁症、抑郁障碍……